血清二高-γ-亚麻酸（DGLA）水平与老年近期心肌梗死后患者的亚油酸和总死亡率呈负相关。
Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction.
机构信息
Department of Cardiology, Stavanger University Hospital, 4068 Stavanger, Norway.
Department of Clinical Science, Faculty of Medicine, University of Bergen, 5020 Bergen, Norway.
出版信息
Nutrients. 2021 Sep 30;13(10):3475. doi: 10.3390/nu13103475.
Dihomo-gamma-linolenic acid (DGLA) is an -6 polyunsaturated fatty acid (PUFA) derived from linoleic acid (LA). The LA:DGLA ratio reflects conversion from LA to DGLA. Low levels of DGLA in serum have been related to poor outcome in myocardial infarction (MI) patients. To assess the association of DGLA and LA:DGLA with total death as a primary aim and incident cardiovascular events as a secondary objective. Baseline samples from 1002 patients, aged 70 to 82 years, included 2-8 weeks after an MI and followed for 2 years, were used. Major adverse clinical events (MACE) consisted of nonfatal MI, unscheduled coronary revascularization, stroke, hospitalization for heart failure or all-cause death. Cox regression analysis was used to relate serum -6 PUFA phospholipid levels (%wt) to the risk of MACE, adjusting for the following: (1) age, sex and body mass index (BMI); (2) adding baseline cod liver oil supplementation; (3) adding prevalent hypertension, chronic kidney disease and diabetes mellitus. Median DGLA level in serum phospholipids was 2.89 (Q1-Q3 2.43-3.38) %wt. DGLA was inversely related to LA and LA:DGLA ratio. There were 208 incident cases of MACE and 55 deaths. In the multivariable analysis, the hazard ratio (HR) for the total death in the three higher quartiles (Q2-4) of DGLA as compared to Q1 was 0.54 (0.31-0.95), with = 0.03 (Model-1), 0.50 (0.28-0.91), with = 0.02 (Model-2), and 0.47 (0.26-0.84), with = 0.012 (Model-3), and non-significant for MACE. Risk of MACE (Model 3) approached borderline significance for LA:DGLA in Q2-4 vs. Q1 [HR 1.42 (1.00-2.04), = 0.052]. Low levels of DGLA were related to a high LA:DGLA ratio and risk of total death in elderly patients with recent MI.
二高γ亚麻酸（DGLA）是一种源自亚油酸（LA）的 -6 多不饱和脂肪酸（PUFA）。LA：DGLA 比值反映了 LA 向 DGLA 的转化。血清中 DGLA 水平低与心肌梗死（MI）患者的不良预后有关。评估 DGLA 和 LA：DGLA 与总死亡率（主要目标）和心血管事件发生率（次要目标）的关系。使用了 1002 名年龄在 70 至 82 岁的患者的基线样本，这些样本在 MI 后 2-8 周内采集，并随访 2 年。主要不良临床事件（MACE）包括非致命性 MI、非计划冠状动脉血运重建、中风、心力衰竭住院或全因死亡。使用 Cox 回归分析将血清 -6 PUFA 磷脂水平（%wt）与 MACE 的风险相关联，调整以下因素：（1）年龄、性别和体重指数（BMI）；（2）加入基线鱼肝油补充剂；（3）加入现患高血压、慢性肾脏病和糖尿病。血清磷脂中二高γ亚麻酸的中位数水平为 2.89（Q1-Q3 2.43-3.38）%wt。DGLA 与 LA 和 LA：DGLA 比值呈负相关。共有 208 例 MACE 事件和 55 例死亡。在多变量分析中，与 Q1 相比，DGLA 三个较高四分位数（Q2-4）的总死亡风险比（HR）为 0.54（0.31-0.95）， = 0.03（模型-1），0.50（0.28-0.91）， = 0.02（模型-2），0.47（0.26-0.84）， = 0.012（模型-3），MACE 无统计学意义。在 Q2-4 与 Q1 相比，LA：DGLA 的 MACE 风险（模型 3）接近边缘显著性[HR 1.42（1.00-2.04）， = 0.052]。在最近发生 MI 的老年患者中，低水平的 DGLA 与高 LA：DGLA 比值和总死亡率风险相关。
Zotero 插件