Knez Marija, Stangoulis James C R, Glibetic Maria, Tako Elad
College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia.
Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia.
Nutrients. 2017 Aug 1;9(8):825. doi: 10.3390/nu9080825.
Zinc (Zn) deficiency is a common aliment predicted to affect 17% of the world's population. Zinc is a vital micronutrient used for over 300 enzymatic reactions and multiple biochemical and structural processes in the body. Although whole blood, plasma, and urine zinc decrease in severe zinc deficiency, accurate assessment of zinc status, especially in mild to moderate deficiency, is difficult as studies with these biomarkers are often contradictory and inconsistent. Hence, as suggested by the World Health Organization, sensitive and specific biological markers of zinc status are still needed. In this review, we provide evidence to demonstrate that the LA:DGLA ratio (linoleic acid:dihomo-γ-linolenic acid ratio) may be a useful additional indicator for assessing Zn status more precisely. However, this biomarker needs to be tested further in order to determine its full potential.
锌（Zn）缺乏是一种常见的营养问题，预计会影响全球17%的人口。锌是一种重要的微量营养素，参与体内300多种酶促反应以及多种生化和结构过程。虽然在严重锌缺乏时全血、血浆和尿液中的锌含量会降低，但由于使用这些生物标志物的研究往往相互矛盾且不一致，因此准确评估锌状态，尤其是轻度至中度缺乏时，具有一定难度。因此，正如世界卫生组织所建议的，仍然需要敏感且特异的锌状态生物标志物。在本综述中，我们提供证据表明，LA:DGLA比值（亚油酸:二高-γ-亚麻酸比值）可能是更精确评估锌状态的一个有用的附加指标。然而，这种生物标志物需要进一步测试，以确定其全部潜力。
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