Clinical Nutrition Unit, Medicine Department, "G. da Saliceto" Hospital, Via Taverna 49, 29121 Piacenza, Italy.
Oncology Unit, Onco-hematology Department, "G. da Saliceto" Hospital, Via Taverna 49, 29121 Piacenza, Italy.
Nutrients. 2021 Sep 30;13(10):3482. doi: 10.3390/nu13103482.
Breast cancer (BC) is a major public health concern and substantial research has shown that adhering to a healthy dietary pattern, such as the Mediterranean Diet (MD), may prevent the onset of cancer and BC relapses. This study aims at specifically investigating the association of MD with circulating dietary-related biomarkers in a cohort of BC survivors. Eighty patients (mean age of 54.9 ± 10.6) with a histologically confirmed diagnosis of BC who had not received any pharmacological or radiotherapy treatment for at least two months were enrolled. Fasting serum lipid-soluble vitamins (retinol, tocopherol), plant pigments (β-carotene, lutein + zeaxanthin, cryptoxanthin, lycopene), inflammatory and oxidative stress markers (ceruloplasmin; haptoglobin; paraoxonases; reactive oxygen molecule; thiol groups, Ferric reducing antioxidant power), and cardiometabolic parameters (body mass index (BMI); glucose; insulin; HOMA-IR; total cholesterol; LDL-cholesterol; HDL-cholesterol; triglycerides) were analyzed. Adherence to the MD was assessed through the Mediterranean Diet Score (MDS) questionnaire. Fasting blood samples were collected for the evaluation of selected biomarkers. MDS resulted positively correlated with β-carotene (r 0.331; < 0.01) and lycopene (r 0.274; < 0.05) and negatively with retinol (r -0.346; < 0.05). Among the investigated inflammatory biomarkers, MDS was only correlated with antioxidant capacity (r 0.256; < 0.05), while none of the investigated cardiometabolic parameters were significantly correlated with this index. The strong significant correlation between β-carotene and MDS encourages us to consider this pro-vitamin as a putative biomarker to take into account for evaluating the adherence to the MD.
乳腺癌（BC）是一个重大的公共卫生问题，大量研究表明，坚持健康的饮食模式，如地中海饮食（MD），可能预防癌症和 BC 的复发。本研究旨在专门研究 MD 与 BC 幸存者队列中循环饮食相关生物标志物的关联。 80 名患者（平均年龄 54.9 ± 10.6）接受了组织学证实的 BC 诊断，并且至少两个月没有接受任何药物或放射治疗。分析了空腹血清脂溶性维生素（视黄醇、生育酚）、植物色素（β-胡萝卜素、叶黄素+玉米黄质、隐黄质、番茄红素）、炎症和氧化应激标志物（铜蓝蛋白；触珠蛋白；对氧磷酶；活性氧分子；巯基、铁还原抗氧化能力）和心血管代谢参数（体重指数（BMI）；血糖；胰岛素；HOMA-IR；总胆固醇；LDL-胆固醇；HDL-胆固醇；甘油三酯）。通过地中海饮食评分（MDS）问卷评估 MD 的依从性。采集空腹血样评估选定的生物标志物。MDS 与 β-胡萝卜素呈正相关（r 0.331；<0.01）和番茄红素（r 0.274；<0.05），与视黄醇呈负相关（r -0.346；<0.05）。在所研究的炎症生物标志物中，MDS 仅与抗氧化能力相关（r 0.256；<0.05），而没有一个心血管代谢参数与该指数显著相关。β-胡萝卜素与 MDS 之间的强显著相关性促使我们考虑将这种前维生素作为评估 MD 依从性的潜在生物标志物。
