De Simone C, Zanzoglu S, Santini G, Ciardi M, Delia S, Sorice F
Infection. 1986;14 Suppl 4:S256-7. doi: 10.1007/BF01661287.
Several factors must be considered before the clinical impact of antimicrobials on the immune function can be determined. No data are available as yet on the influence of ofloxacin, a new fluoro-quinolone, on the lymphocytes of Peyer's patches. The present study offers evidence that murine Peyer's patches are influenced by ofloxacin administered by the oral route for seven days (15 mg/kg). No modifications of the percentage of the Thy 1,2 and SIg positive splenocytes and of the PHA and LPS-induced proliferative responses were observed studying cell suspensions from the spleen of the same animals. An immunotoxic effect of the compound on the cells of Peyer's patches or an impairment of their homing tendency has been postulated.
在确定抗菌药物对免疫功能的临床影响之前，必须考虑几个因素。目前尚无关于新型氟喹诺酮类药物氧氟沙星对派尔集合淋巴结淋巴细胞影响的数据。本研究提供了证据表明，口服氧氟沙星（15毫克/千克）连续七天会影响小鼠的派尔集合淋巴结。在研究同一动物脾脏的细胞悬液时，未观察到Thy 1,2和SIg阳性脾细胞百分比以及PHA和LPS诱导的增殖反应有任何改变。推测该化合物对派尔集合淋巴结细胞有免疫毒性作用或损害其归巢倾向。
