Appelbaum P C, Spangler S K, Sollenberger L
J Antimicrob Chemother. 1986 Dec;18(6):675-9. doi: 10.1093/jac/18.6.675.
Susceptibility of 340 mainly clinically isolated Gram-negative non-fermenters to ciprofloxacin, norfloxacin, amifloxacin, pefloxacin and cefpirome was determined by agar dilution. Ciprofloxacin was most active, with MIC90s against all organisms ranging between less than 0.125 and 4 mg/l. Norfloxacin, amifloxacin and pefloxacin were active against most strains, with MIC90 ranges (mg/l) of 0.5 - 32, 0.25 - 32 and less than 0.125 - 16, respectively. Cefpirome showed less activity than the quinolones on a weight-for-weight basis with MIC90s ranging from 0.5 to greater than 64 mg/l; only fluorescent pseudomonads and Acinetobacter calcoaceticus biotypes haemolyticus, alcaligenes were uniformly susceptible to cefpirome. The broad-spectrum activity of the four quinolones suggests potential use in therapy of infections caused by non-fermenters; cefpirome should be reserved for infections caused by fluorescent pseudomonads and possibly Acinetobacter spp.
采用琼脂稀释法测定了340株主要临床分离的革兰阴性非发酵菌对环丙沙星、诺氟沙星、阿米氟沙星、培氟沙星和头孢匹罗的敏感性。环丙沙星活性最强，对所有菌株的MIC90在小于0.125至4mg/L之间。诺氟沙星、阿米氟沙星和培氟沙星对大多数菌株有活性，MIC90范围（mg/L）分别为0.5 - 32、0.25 - 32和小于0.125 - 16。头孢匹罗在同等重量基础上的活性低于喹诺酮类，MIC90范围为0.5至大于64mg/L；仅荧光假单胞菌和溶血不动杆菌生物型、产碱杆菌对头孢匹罗普遍敏感。四种喹诺酮类的广谱活性表明其在治疗非发酵菌引起的感染方面有潜在用途；头孢匹罗应保留用于治疗由荧光假单胞菌以及可能由不动杆菌属引起的感染。
