Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, AE.
University of Health Sciences, Lahore, PK.
Glob Heart. 2021 Aug 30;16(1):56. doi: 10.5334/gh.943. eCollection 2021.
Sarcopenia is a critical finding in patients with chronic heart failure (CHF). However, the search for a definitive biomarker to predict muscle and functional decline in CHF remains elusive.
We aimed to correlate the circulating levels of selected miRs with the indexes of sarcopenia during healthy aging and in patients with CHF.
We analyzed the association of circulating microRNAs (miRs) levels including miR-21, miR-434-3p, miR424-5p, miR-133a, miR-455-3p and miR-181a with sarcopenia indexes in male, 61-73 years old healthy controls and patients with CHF (N = 89-92/group).
Patients with CHF had lower hand-grip strength (HGS), appendicular skeletal mass index (ASMI) and physical capacity than healthy controls. Circulating miR-21 levels were higher and miR-181a, miR-133a, miR-434-3p and miR-455-3p levels were lower in patients with CHF than healthy controls. Among the sarcopenia indexes, HGS showed the strongest correlation with miR-133a while ASMI showed the strongest correlations with miR-133a, miR-434-3p and miR-455-3p. Among the miRs, miR-434-3p showed the highest area under the curve in testing for sensitivity and specificity for CHF. These changes were associated with higher expressions of the markers of inflammation, oxidative stress and muscle damage in CHF patients.
Taken together, our data show that circulating miRs can be useful markers of muscle health and physical capacity in the sarcopenic elderly with CHF.
肌肉减少症是慢性心力衰竭（CHF）患者的一个重要发现。然而，寻找一种明确的生物标志物来预测 CHF 中的肌肉和功能下降仍然难以捉摸。
我们旨在研究选定的 miRs 循环水平与健康老年人和 CHF 患者的肌肉减少症指标之间的相关性。
我们分析了包括 miR-21、miR-434-3p、miR424-5p、miR-133a、miR-455-3p 和 miR-181a 在内的循环 microRNAs (miRs) 水平与男性 61-73 岁健康对照组和 CHF 患者（每组 89-92 例）肌肉减少症指标的相关性。
与健康对照组相比，CHF 患者的握力（HGS）、四肢骨骼肌质量指数（ASMI）和体力较差。CHF 患者的循环 miR-21 水平较高，miR-181a、miR-133a、miR-434-3p 和 miR-455-3p 水平较低。在肌肉减少症指标中，HGS 与 miR-133a 相关性最强，而 ASMI 与 miR-133a、miR-434-3p 和 miR-455-3p 相关性最强。在这些 miR 中，miR-434-3p 在检测 CHF 的敏感性和特异性方面表现出最高的曲线下面积。这些变化与 CHF 患者炎症、氧化应激和肌肉损伤标志物的高表达有关。
综上所述，我们的数据表明，循环 miRs 可作为 CHF 伴肌肉减少症老年患者肌肉健康和体力的有用标志物。
