Yu Xiao, Zheng Qingyuan, Zhang Qiyao, Zhang Shuijun, He Yuting, Guo Wenzhi
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Cell Dev Biol. 2021 Oct 7;9:752718. doi: 10.3389/fcell.2021.752718. eCollection 2021.
Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed in human cancers. It is significantly associated with many clinical characteristics, such as tumor size, tumor-node-metastasis (TNM) stage, and pathological grade. Additionally, it considerably promotes or suppresses tumor progression by controlling the biological functions of cells. MCM3AP-AS1 is a promising biomarker for cancer diagnosis, prognosis evaluation, and treatment. In this review, we briefly summarized the published studies on the expression, biological function, and regulatory mechanisms of MCM3AP-AS1. We also discussed the clinical applications of MCM3AP-AS1 as a biomarker.
长链非编码RNA（lncRNAs）是一类转录本长度超过200个核苷酸且无蛋白质编码能力的RNA分子。MCM3AP-AS1是一种新型lncRNA，在人类癌症中异常表达。它与许多临床特征显著相关，如肿瘤大小、肿瘤-淋巴结-转移（TNM）分期和病理分级。此外，它通过控制细胞的生物学功能，极大地促进或抑制肿瘤进展。MCM3AP-AS1是一种有前景的癌症诊断、预后评估和治疗生物标志物。在本综述中，我们简要总结了已发表的关于MCM3AP-AS1表达、生物学功能和调控机制的研究。我们还讨论了MCM3AP-AS1作为生物标志物的临床应用。
