Winter Elizabeth M, Kooijman Sander, Appelman-Dijkstra Natasha M, Meijer Onno C, Rensen Patrick Cn, Schilperoort Maaike
Department of Medicine, Division of Endocrinology Leiden University Medical Center Leiden The Netherlands.
Einthoven Laboratory for Experimental Vascular Medicine Leiden The Netherlands.
JBMR Plus. 2021 May 5;5(10):e10504. doi: 10.1002/jbm4.10504. eCollection 2021 Oct.
Physiological circadian (ie, 24-hour) rhythms are critical for bone health. Animal studies have shown that genes involved in the intrinsic molecular clock demonstrate potent circadian expression patterns in bone and that genetic disruption of these clock genes results in a disturbed bone structure and quality. More importantly, circulating markers of bone remodeling show diurnal variation in mice as well as humans, and circadian disruption by, eg, working night shifts is associated with the bone remodeling disorder osteoporosis. In this review, we provide an overview of the current literature on rhythmic bone remodeling and its underlying mechanisms and identify critical knowledge gaps. In addition, we discuss novel (chrono)therapeutic strategies to reduce osteoporosis by utilizing our knowledge on circadian regulation of bone. © 2021 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
生理昼夜节律（即24小时节律）对骨骼健康至关重要。动物研究表明，参与内在分子时钟的基因在骨骼中呈现出强大的昼夜表达模式，并且这些时钟基因的遗传破坏会导致骨骼结构和质量紊乱。更重要的是，骨重塑的循环标志物在小鼠和人类中均表现出昼夜变化，并且诸如值夜班等昼夜节律紊乱与骨重塑疾病骨质疏松症相关。在本综述中，我们概述了有关节律性骨重塑及其潜在机制的当前文献，并确定了关键的知识空白。此外，我们讨论了利用我们对骨骼昼夜调节的了解来减少骨质疏松症的新型（时辰）治疗策略。©2021作者。由Wiley Periodicals LLC代表美国骨与矿物质研究学会出版。
