帕金森病和非典型帕金森综合征患者脑脊液 5-羟吲哚乙酸水平。

Cerebrospinal Fluid Levels of 5-Hydroxyindoleacetic Acid in Parkinson's Disease and Atypical Parkinsonian Syndromes.

机构信息

Department of Neurology, University Hospital Olomouc, Olomouc, Czechia.

Department of Neurology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czechia.

出版信息

Neurodegener Dis. 2021;21(1-2):30-35. doi: 10.1159/000520302. Epub 2021 Oct 25.

DOI:10.1159/000520302

PMID:34695830

Abstract

BACKGROUND

Various cerebrospinal fluid (CSF) biomarkers are studied in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). Several studies found reduced 5-hydroxyindoleacetic acid (5-HIAA), the main serotonin metabolite, in PD. There is little evidence regarding its levels in APS.

METHODS

We measured 5-HIAA in the CSF of 90 PD patients, 16 MSA patients, 26 progressive supranuclear palsy (PSP) patients, 11 corticobasal syndrome (CBS) patients, and 31 controls. We also compared the values in depressed and nondepressed patients.

RESULTS

There was a statistically significant difference in CSF 5-HIAA in PD and MSA compared to the control group (median in PD 15.8 μg/L, in MSA 13.6 μg/L vs. 24.3 μg/L in controls; p = 0.0008 in PD, p = 0.006 in MSA). There was no statistically significant difference in CSF 5-HIAA in PSP and CBS compared to the control group (median in PSP 22.7 μg/L, in CBS 18.7 μg/L vs. 24.3 μg/L in controls; p = 1 in both PSP and CBS). CSF 5-HIAA levels were lower in PD patients with depression compared to PD patients without depression (median 8.34 vs. 18.48, p < 0.0001).

CONCLUSIONS

CSF 5-HIAA is decreased in PD and MSA. The CSF 5-HIAA levels in PSP and CBS did not differ from those of the control group. There was a tendency toward lower CSF 5-HIAA in MSA than in PD; however, the results did not reach statistical significance. These results may be explained by more severe damage of the serotonergic system in synucleinopathies (PD and MSA) than in tauopathies (PSP and CBS).

摘要

背景

各种脑脊液（CSF）生物标志物在帕金森病（PD）和非典型帕金森综合征（APS）中均有研究。多项研究发现，PD 患者的主要 5-羟吲哚乙酸（5-HIAA）代谢物减少。关于 APS 中 5-HIAA 水平的证据很少。

方法

我们测量了 90 例 PD 患者、16 例 MSA 患者、26 例进行性核上性麻痹（PSP）患者、11 例皮质基底节综合征（CBS）患者和 31 例对照者的 CSF 中的 5-HIAA。我们还比较了抑郁和非抑郁患者的数值。

结果

与对照组相比，PD 和 MSA 患者的 CSF 5-HIAA 存在统计学差异（PD 中位数为 15.8μg/L，MSA 中位数为 13.6μg/L，对照组为 24.3μg/L；PD 组 p=0.0008，MSA 组 p=0.006）。与对照组相比，PSP 和 CBS 患者的 CSF 5-HIAA 无统计学差异（PSP 中位数为 22.7μg/L，CBS 中位数为 18.7μg/L，对照组为 24.3μg/L；PSP 和 CBS 组 p 值均为 1）。与无抑郁的 PD 患者相比，有抑郁的 PD 患者的 CSF 5-HIAA 水平较低（中位数为 8.34 与 18.48，p<0.0001）。

结论

PD 和 MSA 患者的 CSF 5-HIAA 降低。PSP 和 CBS 患者的 CSF 5-HIAA 水平与对照组无差异。MSA 患者的 CSF 5-HIAA 水平低于 PD 患者，但结果无统计学意义。这些结果可能是由于在突触核蛋白病（PD 和 MSA）中，5-羟色胺能系统的损伤比在 Tau 病（PSP 和 CBS）中更严重。