Ritzau-Jost Julia, Hutloff Andreas
Institute of Immunology, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.
Vaccines (Basel). 2021 Sep 24;9(10):1074. doi: 10.3390/vaccines9101074.
Follicular helper T cells (Tfh) are the T cell subset providing help to B cells for the generation of high-affinity antibodies and are therefore of key interest for the development of vaccination strategies against infectious diseases. In this review, we will discuss how the generation of Tfh cells and their interaction with B cells in secondary lymphoid organs can be optimized for therapeutic purposes. We will summarize different T cell subsets including Tfh-like peripheral helper T cells (Tph) capable of providing B cell help. In particular, we will highlight the novel concept of T cell/B cell interaction in non-lymphoid tissues as an important element for the generation of protective antibodies directly at the site of pathogen invasion.
滤泡辅助性T细胞（Tfh）是为B细胞提供帮助以产生高亲和力抗体的T细胞亚群，因此对于开发针对传染病的疫苗策略至关重要。在本综述中，我们将讨论如何为治疗目的优化Tfh细胞的产生及其在次级淋巴器官中与B细胞的相互作用。我们将总结不同的T细胞亚群，包括能够为B细胞提供帮助的类Tfh外周辅助性T细胞（Tph）。特别是，我们将强调非淋巴组织中T细胞/B细胞相互作用这一新概念，它是直接在病原体入侵部位产生保护性抗体的重要因素。
