Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.
ENT Research Lab., Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil.
Int J Environ Res Public Health. 2023 Jan 20;20(3):1939. doi: 10.3390/ijerph20031939.
In this study, we aimed to investigate the specific-antibody response to the COVID-19 vaccination and the immunophenotyping of T cells in older adults who were engaged or not in an exercise training program before the pandemic.
Ninety-three aged individuals (aged between 60 and 85 years) were separated into 3 groups: practitioners of physical exercise vaccinated with CoronaVac (PE-Co, = 46), or vaccinated with ChadOx-1 (PE-Ch, = 23), and non-practitioners vaccinated with ChadOx-1 (NPE-Ch, = 24). Blood samples were collected before (pre) and 30 days after vaccination with the second vaccine dose.
Higher IgG levels and immunogenicity were found in the PE-Ch and NPE-Ch groups, whereas increased IgA levels were found only in the PE-Ch group post-vaccination. The PE-Co group showed a positive correlation between the IgA and IgG values, and lower IgG levels post-vaccination were associated with age. Significant alterations in the percentage of naive (CD28+CD57-), double-positive (CD28+CD57+), and senescent (CD28-CD57+) CD4+ T and CD8+ T cells were found post-vaccination, particularly in the PE-Ch group.
The volunteers vaccinated with the ChadOx-1 presented not only a better antibody response but also a significant modulation in the percentage of T cell profiles, mainly in the previously exercised group.
在这项研究中，我们旨在研究在大流行之前参与或未参与运动训练计划的老年人对 COVID-19 疫苗的特异性抗体反应和 T 细胞免疫表型。
93 名年龄在 60 至 85 岁之间的老年人被分为 3 组：接种科兴疫苗的锻炼者（PE-Co，n=46）、接种阿斯利康疫苗的锻炼者（PE-Ch，n=23）和未接种阿斯利康疫苗的锻炼者（NPE-Ch，n=24）。在接种第二剂疫苗前（pre）和接种后 30 天收集血液样本。
PE-Ch 和 NPE-Ch 组的 IgG 水平和免疫原性更高，而仅在 PE-Ch 组中发现接种后 IgA 水平升高。PE-Co 组的 IgA 和 IgG 值之间存在正相关，接种后 IgG 水平较低与年龄有关。接种后，CD4+T 和 CD8+T 细胞的幼稚（CD28+CD57-）、双阳性（CD28+CD57+）和衰老（CD28-CD57+）细胞的百分比发生了显著变化，特别是在 PE-Ch 组中。
接种阿斯利康疫苗的志愿者不仅表现出更好的抗体反应，而且 T 细胞表型的百分比也发生了显著变化，主要是在之前锻炼的组中。
