2019冠状病毒病疫苗：特殊人群中安全性与有效性的全面综述
COVID-19 Vaccinations: A Comprehensive Review of Their Safety and Efficacy in Special Populations.
作者信息
Yan Zhipeng, Yang Ming, Lai Ching-Lung
机构信息
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
出版信息
Vaccines (Basel). 2021 Sep 28;9(10):1097. doi: 10.3390/vaccines9101097.
Abstract
COVID-19 has been spreading worldwide since late 2019. There is no definitive cure to date. Global vaccination programs are urgently required to confer herd immunity, reducing the incidence of COVID-19 infections and associated morbidity and mortality. However, a significant proportion of special populations are hesitant to receive vaccination due to their special conditions, namely, age (pediatrics and geriatrics), immunocompromised state, autoimmune diseases, chronic cardiovascular and pulmonary conditions, active or treated cancers, and pregnancy. This review aims to evaluate the existing evidence of COVID-19 vaccinations on these special populations and to provide clues to guide vaccination decision making to balance the benefits and risks of vaccinations.
摘要
自2019年末以来，新冠病毒病（COVID-19）一直在全球范围内传播。迄今为止尚无确切的治愈方法。迫切需要全球疫苗接种计划来实现群体免疫，降低COVID-19感染率以及相关的发病率和死亡率。然而，相当一部分特殊人群因其特殊状况而对接种疫苗犹豫不决，这些特殊状况包括年龄（儿科和老年科）、免疫功能低下状态、自身免疫性疾病、慢性心血管和肺部疾病、活动性癌症或已接受治疗的癌症以及妊娠。本综述旨在评估关于这些特殊人群接种COVID-19疫苗的现有证据，并提供线索以指导疫苗接种决策，平衡疫苗接种的益处和风险。
相似文献
1
COVID-19 Vaccinations: A Comprehensive Review of Their Safety and Efficacy in Special Populations.2019冠状病毒病疫苗：特殊人群中安全性与有效性的全面综述
Vaccines (Basel). 2021 Sep 28;9(10):1097. doi: 10.3390/vaccines9101097.
2
COVID-19 vaccines: concerns beyond protective efficacy and safety.COVID-19 疫苗：除了保护效力和安全性之外的关注点。
Expert Rev Vaccines. 2021 Aug;20(8):1013-1025. doi: 10.1080/14760584.2021.1949293. Epub 2021 Jul 5.
3
Coronavirus disease 2019 (Covid-19) vaccination recommendations in special populations and patients with existing comorbidities.新型冠状病毒病 2019（COVID-19）疫苗在特殊人群和合并症患者中的接种建议。
Rev Med Virol. 2022 May;32(3):e2309. doi: 10.1002/rmv.2309. Epub 2021 Oct 22.
4
Feasibility of Provision and Vaccine Hesitancy at a Central Hospital COVID-19 Vaccination Site in South Africa after Four Waves of the Pandemic.在南非一家中心医院新冠疫苗接种点经历四波疫情后疫苗供应的可行性及疫苗犹豫情况
Diseases. 2024 May 24;12(6):113. doi: 10.3390/diseases12060113.
5
A scoping review on the decision-making dynamics for accepting or refusing the COVID-19 vaccination among adolescent and youth populations.一项关于青少年和青年群体接受或拒绝 COVID-19 疫苗接种的决策动态的范围综述。
BMC Public Health. 2023 Apr 28;23(1):784. doi: 10.1186/s12889-023-15717-5.
6
COVID-19 vaccine hesitancy in a representative working-age population in France: a survey experiment based on vaccine characteristics.法国具有代表性的工作年龄人群中对新冠疫苗的犹豫态度：一项基于疫苗特性的调查实验
Lancet Public Health. 2021 Apr;6(4):e210-e221. doi: 10.1016/S2468-2667(21)00012-8. Epub 2021 Feb 6.
7
Vaccination of special populations: Protecting the vulnerable.特殊人群的疫苗接种：保护弱势群体。
Vaccine. 2016 Dec 20;34(52):6681-6690. doi: 10.1016/j.vaccine.2016.11.015. Epub 2016 Nov 18.
8
9
Individual preferences for COVID-19 vaccination in China.中国人对 COVID-19 疫苗接种的个体偏好。
Vaccine. 2021 Jan 8;39(2):247-254. doi: 10.1016/j.vaccine.2020.12.009. Epub 2020 Dec 5.
10
Challenges of breastfeeding during COVID-19 and baby friendly protocols adopted at a maternity health center in the northern Emirates of UAE: a comprehensive review.新冠疫情期间母乳喂养的挑战，以及阿联酋北部酋长国一家母婴保健中心采用的爱婴医院协议：全面综述。
J Health Popul Nutr. 2024 May 14;43(1):65. doi: 10.1186/s41043-024-00544-0.
引用本文的文献
1
A Study of Transplacental Transfer of SARS-CoV-2 Antibodies in COVID-19 Vaccinated Women in Mumbai, India.印度孟买接种新冠疫苗的女性中 SARS-CoV-2 抗体经胎盘转移的研究。
Cureus. 2025 Jul 10;17(7):e87643. doi: 10.7759/cureus.87643. eCollection 2025 Jul.
2
Rates of SARS-CoV-2 Breakthrough Infection or Severe COVID-19 and Associated Risk Factors After Primary and Booster Vaccination Against COVID-19 in the Netherlands.荷兰接种新冠疫苗初种和加强针后新冠病毒突破性感染或重症新冠肺炎的发生率及相关风险因素
Vaccines (Basel). 2025 May 26;13(6):564. doi: 10.3390/vaccines13060564.
3
Clinical practice guidelines and expert consensus statements on rehabilitation for patients with COVID-19: a systematic review.临床实践指南和专家共识声明：COVID-19 患者康复治疗的系统评价。
BMJ Open. 2024 Sep 10;14(9):e086301. doi: 10.1136/bmjopen-2024-086301.
4
Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer.CoronaVac 和 ChAdOx1 疫苗在类风湿关节炎患者中预防 SARS-CoV-2 的安全性：来自巴西多中心研究 safer 的数据。
Adv Rheumatol. 2024 Aug 12;64(1):58. doi: 10.1186/s42358-024-00397-5.
5
Efficacy and safety of casirivimab and imdevimab for preventing and treating COVID-19: a systematic review and meta-analysis.卡西瑞维单抗和英夫西单抗预防和治疗新型冠状病毒肺炎的疗效和安全性：一项系统评价和荟萃分析
J Thorac Dis. 2024 Jun 30;16(6):3606-3622. doi: 10.21037/jtd-23-1604. Epub 2024 Jun 11.
6
Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms.有呼吸道症状和无呼吸道症状入院的COVID-19患者的特征及结局
Heliyon. 2024 May 4;10(10):e29591. doi: 10.1016/j.heliyon.2024.e29591. eCollection 2024 May 30.
7
The safety and immunogenicity of vaccines administered to pregnant women living with HIV: a systematic review and meta-analysis.给感染艾滋病毒的孕妇接种疫苗的安全性和免疫原性：一项系统评价和荟萃分析。
EClinicalMedicine. 2024 Feb 2;69:102448. doi: 10.1016/j.eclinm.2024.102448. eCollection 2024 Mar.
8
The disparity in hesitancy toward COVID-19 vaccination between older individuals in nursing homes and those in the community in Taizhou, China.中国泰州养老院和社区老年人对 COVID-19 疫苗接种犹豫不决的差异。
BMC Geriatr. 2023 Dec 9;23(1):828. doi: 10.1186/s12877-023-04518-5.
9
Anti-SARS-CoV-2 Antibody Level Is Associated with a History of COVID-19 Infection and mRNA Vaccination in Patients with Diabetes.抗SARS-CoV-2抗体水平与糖尿病患者的COVID-19感染史和mRNA疫苗接种情况相关。
Vaccines (Basel). 2023 Aug 27;11(9):1424. doi: 10.3390/vaccines11091424.
10
In-silico study: docking simulation and molecular dynamics of peptidomimetic fullerene-based derivatives against SARS-CoV-2 M.计算机模拟研究：基于肽模拟富勒烯的衍生物对严重急性呼吸综合征冠状病毒2 M的对接模拟和分子动力学
3 Biotech. 2023 Jun;13(6):185. doi: 10.1007/s13205-023-03608-w. Epub 2023 May 13.
本文引用的文献
1
COVID-19 Vaccine Hesitancy and Acceptance Among Individuals With Cancer, Autoimmune Diseases, or Other Serious Comorbid Conditions: Cross-sectional, Internet-Based Survey.COVID-19 疫苗犹豫和接受情况在癌症、自身免疫性疾病或其他严重合并症患者中的调查：基于互联网的横断面研究。
JMIR Public Health Surveill. 2022 Jan 5;8(1):e29872. doi: 10.2196/29872.
2
Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine.针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和BNT162b2 mRNA新冠疫苗的抗体从母体到新生儿的高效转移。
J Clin Invest. 2021 Oct 1;131(19). doi: 10.1172/JCI154834.
3
Neutralisation of ZF2001-elicited antisera to SARS-CoV-2 variants.ZF2001诱导的抗血清对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体的中和作用。
Lancet Microbe. 2021 Oct;2(10):e494. doi: 10.1016/S2666-5247(21)00217-2. Epub 2021 Aug 20.
4
Long COVID-19 Syndrome: A Comprehensive Review of Its Effect on Various Organ Systems and Recommendation on Rehabilitation Plans.新冠长期综合征：对其对各器官系统影响的全面综述及康复计划建议
Biomedicines. 2021 Aug 5;9(8):966. doi: 10.3390/biomedicines9080966.
5
Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting.BNT162b2 mRNA 新冠疫苗在全国范围内使用的安全性。
N Engl J Med. 2021 Sep 16;385(12):1078-1090. doi: 10.1056/NEJMoa2110475. Epub 2021 Aug 25.
6
Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies.COVID-19（CoviVac）灭活疫苗在临床前研究中的长期体液免疫原性、安全性和保护效力。
Emerg Microbes Infect. 2021 Dec;10(1):1790-1806. doi: 10.1080/22221751.2021.1971569.
7
Iran hopes to defeat COVID with home-grown crop of vaccines.伊朗希望凭借本土生产的一批疫苗战胜新冠疫情。
Nature. 2021 Aug;596(7873):475. doi: 10.1038/d41586-021-02216-z.
8
Age and Gender Disparities in Adverse Events Following COVID-19 Vaccination: Real-World Evidence Based on Big Data for Risk Management.COVID-19疫苗接种后不良事件中的年龄和性别差异：基于大数据进行风险管理的真实世界证据
Front Med (Lausanne). 2021 Jul 19;8:700014. doi: 10.3389/fmed.2021.700014. eCollection 2021.
9
Myocarditis and Pericarditis After Vaccination for COVID-19.接种 COVID-19 疫苗后的心肌炎和心包炎。
JAMA. 2021 Sep 28;326(12):1210-1212. doi: 10.1001/jama.2021.13443.
10
In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain.COVID-19 免疫抑制患者的住院死亡率：来自西班牙全国队列的分析。
PLoS One. 2021 Aug 3;16(8):e0255524. doi: 10.1371/journal.pone.0255524. eCollection 2021.
Zotero 插件