Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany;
BerlinAnalytix GmbH, Berlin, Germany.
In Vivo. 2021 Nov-Dec;35(6):3011-3017. doi: 10.21873/invivo.12596.
In many medical disciplines, the process of drilling into the bone plays a crucial role for the implantation or fixation of implants or reconstruction plates. During the bone drilling process, heat is generated on the drill head and within the surrounding tissue. As a result, the increased temperature can lead to thermal damage and related necrosis of the (bone) tissue. This tissue damage is dependent on different drilling parameters and can have important influence on the following tissue healing cascade and finally on implant surveillance. In this context, the present short review elucidates the current state of scientific knowledge with regard to the heat-triggering factors during the bony drilling process and how these factors can be better understood and prevented, now and in the future, through new research approaches. External and internal influencing factors during the drilling process are distinguished and methods to examine the temperature changes are compared. This mini-review further demonstrates first preliminary results of the inflammatory tissue reactions to inadequate drilling processes. Furthermore, possible solutions of new standardized ex vivo-measurement methods to better understand the factors influencing the development of heat and to reduce animal experiments are herein discussed.
在许多医学领域中，钻入骨头的过程对于植入物或固定板的植入或固定起着至关重要的作用。在骨钻过程中，钻头和周围组织中会产生热量。因此，温度升高会导致热损伤和相关的（骨）组织坏死。这种组织损伤取决于不同的钻孔参数，并可能对随后的组织愈合级联反应产生重要影响，最终对植入物的监测产生影响。在这方面，本文综述了目前科学界对骨钻过程中引起热的因素的认识，并探讨了如何通过新的研究方法来更好地理解和预防这些因素，无论是现在还是将来。本文区分了钻孔过程中的外部和内部影响因素，并比较了检查温度变化的方法。本综述进一步展示了对不充分的钻孔过程引起的炎症性组织反应的初步结果。此外，还讨论了新的标准化离体测量方法的可能解决方案，以更好地了解影响热发展的因素，并减少动物实验。
