Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China.
Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China;
J Immunol. 2021 Dec 1;207(11):2770-2784. doi: 10.4049/jimmunol.2100469. Epub 2021 Oct 25.
Circular RNAs (circRNAs) are a subgroup of endogenous noncoding RNA that is covalently closed rings and widely expressed. In recent years, there is accumulating evidence indicating that circRNAs are a class of important regulators, which play an important role in various biological processes. However, the biological functions and regulation mechanism of circRNAs in lower vertebrates are little known. In this study, we discovered a circRNA Samd4a (circSamd4a) that is related to the antiviral immune response of teleost fish. It can act as a key regulator of the host's antiviral response and play a key role in inhibiting replication. Further studies have shown that circSamd4a may act as a competing endogenous RNA, which can enhance the STING-mediated NF-κB/IRF3 signaling pathway by adsorbing miR-29a-3p, thereby enhancing the antiviral immune response. Therefore, circSamd4a plays an active regulatory role in the antiviral immune response of bony fish. Our research results provide a strong foundation for circular RNA to play a regulatory role in the antiviral immune response of teleost fish.
环状 RNA（circRNAs）是一类具有共价闭合环的内源性非编码 RNA，广泛表达。近年来，越来越多的证据表明，circRNAs 是一类重要的调控因子，在各种生物学过程中发挥着重要作用。然而，circRNAs 在低等脊椎动物中的生物学功能和调控机制知之甚少。在本研究中，我们发现了一个与硬骨鱼类抗病毒免疫反应相关的环状 RNA Samd4a（circSamd4a）。它可以作为宿主抗病毒反应的关键调控因子，并在抑制病毒复制中发挥关键作用。进一步的研究表明，circSamd4a 可能作为一种竞争性内源 RNA，通过吸附 miR-29a-3p 增强 STING 介导的 NF-κB/IRF3 信号通路，从而增强抗病毒免疫反应。因此，circSamd4a 在硬骨鱼类的抗病毒免疫反应中发挥着积极的调控作用。我们的研究结果为环状 RNA 在硬骨鱼类抗病毒免疫反应中发挥调控作用提供了有力的依据。
