• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

加强暴露科学在欧盟化学政策中的应用,作为 2020-2030 年欧洲暴露科学战略的一部分。

Enhancing the use of exposure science across EU chemical policies as part of the European Exposure Science Strategy 2020-2030.

机构信息

European Commission, Joint Research Centre, Directorate for Space, Security and Migration, Geel, Belgium.

European Chemical Industry Council (Cefic), Brussels, Belgium.

出版信息

J Expo Sci Environ Epidemiol. 2022 Jul;32(4):513-525. doi: 10.1038/s41370-021-00388-4. Epub 2021 Oct 25.

DOI:10.1038/s41370-021-00388-4
PMID:34697409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9349036/
Abstract

BACKGROUND

A scientific framework on exposure science will boost the multiuse of exposure knowledge across EU chemicals-related policies and improve risk assessment, risk management and communication across EU safety, security and sustainability domains.

OBJECTIVE

To stimulate public and private actors to align and strengthen the cross-policy adoption of exposure assessment data, methods and tools across EU legislation.

METHODS

By mapping and analysing the EU regulatory landscape making use of exposure information, policy and research challenges and key areas of action are identified and translated into opportunities enhancing policy and scientific efficiency.

RESULTS

Identified key areas of actions are to develop a common scientific exposure assessment framework, supported by baseline acceptance criteria and a shared knowledge base enhancing exchangeability and acceptability of exposure knowledge within and across EU chemicals-related policies. Furthermore, such framework will improve communication and management across EU chemical safety, security and sustainability policies comprising sourcing, manufacturing and global trade of goods and waste management. In support of building such a common framework and its effective use in policy and industry, exposure science innovation needs to be better embedded along the whole policymaking cycle, and be integrated into companies' safety and sustainability management systems. This will help to systemically improve regulatory risk management practices.

SIGNIFICANCE

This paper constitutes an important step towards the implementation of the EU Green Deal and its underlying policy strategies, such as the Chemicals Strategy for Sustainability.

摘要

背景

暴露科学的科学框架将促进暴露知识在整个欧盟化学相关政策中的多用途应用,并改善整个欧盟安全、保障和可持续性领域的风险评估、风险管理和沟通。

目的

鼓励公共和私人行为者调整并加强整个欧盟立法中暴露评估数据、方法和工具的跨政策采用。

方法

通过利用暴露信息、政策和研究挑战来绘制和分析欧盟监管格局,确定并转化为增强政策和科学效率的机会的关键行动领域。

结果

确定的关键行动领域是制定一个共同的科学暴露评估框架,该框架得到基准接受标准和共享知识库的支持,从而增强暴露知识在整个欧盟化学相关政策内部和之间的可交换性和可接受性。此外,这样的框架将改善整个欧盟化学安全、保障和可持续性政策的沟通和管理,这些政策包括货物的来源、制造和全球贸易以及废物管理。为了支持建立这样一个共同框架及其在政策和工业中的有效使用,需要更好地将暴露科学创新嵌入整个决策制定周期,并将其纳入公司的安全和可持续性管理系统。这将有助于系统地改进监管风险管理实践。

意义

本文是朝着实施欧盟绿色协议及其基础政策战略(如可持续性化学战略)迈出的重要一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f7/9349036/d9cc9baadcc9/41370_2021_388_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f7/9349036/2c9fbafeadad/41370_2021_388_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f7/9349036/40564cb87022/41370_2021_388_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f7/9349036/d9cc9baadcc9/41370_2021_388_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f7/9349036/2c9fbafeadad/41370_2021_388_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f7/9349036/40564cb87022/41370_2021_388_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9f7/9349036/d9cc9baadcc9/41370_2021_388_Fig3_HTML.jpg

相似文献

1
Enhancing the use of exposure science across EU chemical policies as part of the European Exposure Science Strategy 2020-2030.加强暴露科学在欧盟化学政策中的应用,作为 2020-2030 年欧洲暴露科学战略的一部分。
J Expo Sci Environ Epidemiol. 2022 Jul;32(4):513-525. doi: 10.1038/s41370-021-00388-4. Epub 2021 Oct 25.
2
Advancing exposure data analytics and repositories as part of the European Exposure Science Strategy 2020-2030.推进暴露数据分析与资料库建设,作为2020 - 2030年欧洲暴露科学战略的一部分。
Environ Int. 2022 Dec;170:107610. doi: 10.1016/j.envint.2022.107610. Epub 2022 Oct 30.
3
A research roadmap for complementary and alternative medicine - what we need to know by 2020.补充和替代医学研究路线图——到2020年我们需要了解的内容。
Forsch Komplementmed. 2014;21(2):e1-16. doi: 10.1159/000360744. Epub 2014 Mar 24.
4
Strengthening and rationalizing pharmacovigilance in the EU: where is Europe heading to? A review of the new EU legislation on pharmacovigilance.加强和合理化欧盟的药物警戒:欧洲将走向何方?对新的欧盟药物警戒立法的审查。
Drug Saf. 2011 Mar 1;34(3):187-97. doi: 10.2165/11586620-000000000-00000.
5
The EU Green Deal's ambition for a toxic-free environment: Filling the gap for science-based policymaking.欧盟绿色协议追求无毒环境的雄心:填补基于科学的决策制定的空白。
Integr Environ Assess Manag. 2021 Nov;17(6):1105-1113. doi: 10.1002/ieam.4429. Epub 2021 May 20.
6
The Minderoo-Monaco Commission on Plastics and Human Health.美诺集团-摩纳哥基金会塑料与人体健康委员会
Ann Glob Health. 2023 Mar 21;89(1):23. doi: 10.5334/aogh.4056. eCollection 2023.
7
Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020-2030.将人类生物监测发展成为2020 - 2030年欧洲暴露科学战略中的21世纪工具箱。
Environ Int. 2022 Oct;168:107476. doi: 10.1016/j.envint.2022.107476. Epub 2022 Aug 28.
8
"Working the system"--British American tobacco's influence on the European union treaty and its implications for policy: an analysis of internal tobacco industry documents.“玩转体制”——英美烟草对欧盟条约的影响及其对政策的启示:对内部烟草业文件的分析。
PLoS Med. 2010 Jan 12;7(1):e1000202. doi: 10.1371/journal.pmed.1000202.
9
Is the EU chemicals strategy for sustainability a green deal?欧盟的化学品可持续发展战略是一项绿色协议吗?
Regul Toxicol Pharmacol. 2023 Mar;139:105356. doi: 10.1016/j.yrtph.2023.105356. Epub 2023 Feb 8.
10
Upholding the EU's Commitment to 'Animal Testing as a Last Resort' Under REACH Requires a Paradigm Shift in How We Assess Chemical Safety to Close the Gap Between Regulatory Testing and Modern Safety Science.在 REACH 法规下坚持欧盟“动物测试作为最后手段”的承诺,需要在我们评估化学品安全性的方法上进行范式转变,以缩小监管测试与现代安全科学之间的差距。
Altern Lab Anim. 2021 Jul;49(4):122-132. doi: 10.1177/02611929211040824. Epub 2021 Aug 30.

引用本文的文献

1
From Ambition to Action: Navigating Obstacles and Opportunities of "Safe and Sustainable by Design".从雄心到行动:应对“设计安全与可持续”的障碍与机遇
Environ Sci Technol. 2025 Jul 29;59(29):14832-14841. doi: 10.1021/acs.est.4c09863. Epub 2025 Jul 18.
2
A systematic review of the risk management frameworks for potentially toxic chemical elements.潜在有毒化学元素风险管理框架的系统评价。
Toxicol Ind Health. 2023 Dec;39(12):679-686. doi: 10.1177/07482337231209092. Epub 2023 Oct 18.
3
Review of generic scenario environmental release and occupational exposure models used in chemical risk assessment.

本文引用的文献

1
Exposure modelling in Europe: how to pave the road for the future as part of the European Exposure Science Strategy 2020-2030.欧洲暴露建模:如何为未来铺平道路,作为 2020-2030 年欧洲暴露科学战略的一部分。
J Expo Sci Environ Epidemiol. 2022 Jul;32(4):499-512. doi: 10.1038/s41370-022-00455-4. Epub 2022 Aug 2.
2
Exposure and Toxicity Characterization of Chemical Emissions and Chemicals in Products: Global Recommendations and Implementation in USEtox.产品中化学排放物和化学品的暴露与毒性特征:全球建议及在USEtox中的实施
Int J Life Cycle Assess. 2021 May;26(5):899-915. doi: 10.1007/s11367-021-01889-y. Epub 2021 Apr 5.
3
用于化学风险评估的一般情景环境释放和职业暴露模型综述。
J Occup Environ Hyg. 2023 Nov;20(11):545-562. doi: 10.1080/15459624.2023.2242896. Epub 2023 Sep 14.
4
Cutting-edge computational chemical exposure research at the U.S. Environmental Protection Agency.美国环保署的前沿计算化学暴露研究。
Environ Int. 2023 Aug;178:108097. doi: 10.1016/j.envint.2023.108097. Epub 2023 Jul 13.
5
Effect of Pesticide Exposure over DNA Damage in Farmers from Los Reyes, Michoacan in Mexico.农药暴露对墨西哥米却肯州洛斯雷耶斯农民DNA损伤的影响。
Toxics. 2023 Jan 26;11(2):122. doi: 10.3390/toxics11020122.
6
Environmental ranking of European industrial facilities by toxicity and global warming potentials.基于毒性和全球变暖潜能对欧洲工业设施的环境排名。
Sci Rep. 2023 Jan 31;13(1):1772. doi: 10.1038/s41598-022-25750-w.
7
Pandemic management requires exposure science.大流行管理需要暴露科学。
Environ Int. 2022 Nov;169:107470. doi: 10.1016/j.envint.2022.107470. Epub 2022 Aug 20.
Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco.
旧金山母婴对环境化学物质的可疑筛查、优先级排序和确认。
Environ Sci Technol. 2021 Apr 20;55(8):5037-5049. doi: 10.1021/acs.est.0c05984. Epub 2021 Mar 16.
4
Empowering large chemical knowledge bases for exposomics: PubChemLite meets MetFrag.为暴露组学增强大型化学知识库:PubChemLite与MetFrag的结合
J Cheminform. 2021 Mar 8;13(1):19. doi: 10.1186/s13321-021-00489-0.
5
We need a global science-policy body on chemicals and waste.我们需要一个关于化学品和废物的全球科学政策机构。
Science. 2021 Feb 19;371(6531):774-776. doi: 10.1126/science.abe9090.
6
Integrating endocrine-related health effects into comparative human toxicity characterization.将与内分泌相关的健康影响纳入比较人类毒性特征描述中。
Sci Total Environ. 2021 Mar 25;762:143874. doi: 10.1016/j.scitotenv.2020.143874. Epub 2020 Dec 3.
7
An overview of the uses of per- and polyfluoroalkyl substances (PFAS).全氟和多氟烷基物质 (PFAS) 的用途概述。
Environ Sci Process Impacts. 2020 Dec 1;22(12):2345-2373. doi: 10.1039/d0em00291g. Epub 2020 Oct 30.
8
Biomonitoring as an Underused Exposure Assessment Tool in Occupational Safety and Health Context-Challenges and Way Forward.生物监测在职业安全与健康背景下作为一种未充分利用的暴露评估工具——挑战与未来方向。
Int J Environ Res Public Health. 2020 Aug 13;17(16):5884. doi: 10.3390/ijerph17165884.
9
Food Safety Regulatory Research Needs 2030.2030年食品安全监管研究需求
EFSA J. 2019 Jul 1;17(7):e170622. doi: 10.2903/j.efsa.2019.e170622. eCollection 2019 Jul.
10
Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals.关于多种化学品联合暴露对人类健康、动物健康和生态风险评估的统一方法指南。
EFSA J. 2019 Mar 25;17(3):e05634. doi: 10.2903/j.efsa.2019.5634. eCollection 2019 Mar.