3D打印壳聚糖-果胶水凝胶：从流变学表征到支架开发与评估
3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment.
作者信息
Zarandona Iratxe, Bengoechea Carlos, Álvarez-Castillo Estefanía, de la Caba Koro, Guerrero Antonio, Guerrero Pedro
机构信息
BIOMAT Research Group, University of the Basque Country (UPV/EHU), Escuela de Ingeniería de Gipuzkoa, Plaza de Europa 1, 20018 Donostia-San Sebastián, Spain.
Departamento de Ingeniería Química, Universidad de Sevilla, Escuela Politécnica Superior, Calle Virgen de África, 7, 41011 Sevilla, Spain.
出版信息
Gels. 2021 Oct 21;7(4):175. doi: 10.3390/gels7040175.
Chitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccharides, as observed by FTIR analysis. Since systems with high concentration of pectin showed aggregations, the system composed of 2 wt% chitosan and 2 wt% pectin (CHI2PEC2) was selected for 3D printing. 3D printed scaffolds showed good shape accuracy, and SEM and XRD analyses revealed a homogeneous and amorphous structure. Moreover, scaffolds were stable and kept their shape and size after a cycle of compression sweeps. Their integrity was also maintained after immersion in PBS at 37 °C, showing a high swelling capacity, suitable for exudate absorption in wound healing applications.
制备了壳聚糖-果胶水凝胶，并对其流变学性质进行了评估，以便选择最佳体系通过3D打印来制备支架。如傅里叶变换红外光谱（FTIR）分析所示，由于两种多糖之间形成的物理相互作用，水凝胶表现出具有剪切变稀流动特性的弱凝胶行为。由于高浓度果胶体系出现团聚现象，因此选择由2 wt%壳聚糖和2 wt%果胶组成的体系（CHI2PEC2）进行3D打印。3D打印的支架显示出良好的形状精度，扫描电子显微镜（SEM）和X射线衍射（XRD）分析表明其结构均匀且无定形。此外，支架具有稳定性，在压缩扫描循环后保持其形状和尺寸。将其浸入37°C的磷酸盐缓冲盐水（PBS）中后，其完整性也得以保持，显示出高膨胀能力，适用于伤口愈合应用中的渗出液吸收。
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