Influence of Host-Related Factors and Exposure to Mosquito Bites on the Dynamics of Antibody Response to Antigens.

Humoral immunity to is acquired after repeated infections, and can lead to clinical protection. This study aimed to evaluate how human-, parasite-, and environment-related determinants can modulate the dynamics of IgG responses to after an infection. Individuals ( = 68, average age = 8.2 years) with uncomplicated malaria were treated with ACT and followed up for 42 days. IgG responses to merozoite antigens (MSP1MSP3AMA1GLURP-R0), to whole schizont extract (Schz), and to gSG6-P1 and Nterm-34 kDa salivary peptides were measured. Regression analyses were used to identify factors that influence the dynamics of IgG response to antigen between D0 and D42, including demographic and biological factors and the level of exposure to mosquito bites. The dynamics of IgG response to differed according to the antigen. According to multivariate analysis, IgG responses to Schz and to GLURP-R0 appear to be affected by exposure to saliva and are associated with age, parasite density, and anti- pre-existing immune response at study inclusion. The present work shows that human exposure to saliva may contribute, in addition to other factors, to the regulation of anti- immune responses during a natural infection.