Marine Biodiscovery, School of Chemistry and Ryan Institute, NUI Galway, University Road, Galway, H91TK33, Ireland.
Prog Chem Org Nat Prod. 2021;116:1-36. doi: 10.1007/978-3-030-80560-9_1.
The term "marine biodiscovery" has been recently been adopted to describe the area of marine natural products dedicated to the search of new drugs. Several maritime countries such as Australia, New Zealand, South Korea, and Japan as well as some European countries have invested significantly in this area of research over the last 50 years. In the late 2000s, research in this field has received significant interest and support in Ireland for exploring new marine bioresources from the nutrient-rich waters of the Northeastern Atlantic Ocean. Despite undeniable success exemplified by the marketing of new drugs, especially in oncology, the integration of new technical but also environmental aspects should be considered. Indeed, global change, particularly in our oceans, such as climate change, biodiversity loss, and the emergence of microbial pathogens, not only affects the environment but ultimately contributes to social inequalities. In this contribution, new avenues and best practices are proposed, such as the development of biorepositories and shared data for the future of marine biodiscovery research. The extension of this type of scientific work will allow humanity to finally make the optimum use of marine bioresources.
“海洋生物发现”一词最近被采用，用于描述专门寻找新药的海洋天然产物领域。在过去的 50 年里，澳大利亚、新西兰、韩国、日本和一些欧洲国家等几个海洋国家在这一研究领域投入了大量资金。在 2000 年代后期，爱尔兰对东北大西洋营养丰富的水域中的新海洋生物资源进行了探索，该领域的研究受到了极大的关注和支持。尽管新药营销取得了不可否认的成功，特别是在肿瘤学方面，但应考虑纳入新的技术和环境方面。事实上，全球变化，特别是在我们的海洋中，如气候变化、生物多样性丧失和微生物病原体的出现，不仅影响环境，最终还导致社会不平等。在这篇文章中，提出了新的途径和最佳实践，例如生物库的发展和共享数据，以促进海洋生物发现研究的未来。这种科学工作的扩展将使人类最终能够充分利用海洋生物资源。
