非侵入性检测手段在嗜酸性粒细胞性食管炎中的应用：是否已经准备就绪？
Noninvasive tests for eosinophilic esophagitis: Ready for use?
机构信息
Division of Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, Virginia; Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Division of Allergy and Immunology, Departments of Pediatrics and Medicine, University of California San Diego, San Diego, California; Rady Children's Hospital-San Diego, San Diego, California.
出版信息
Ann Allergy Asthma Immunol. 2022 Jul;129(1):27-34. doi: 10.1016/j.anai.2021.10.025. Epub 2021 Oct 24.
OBJECTIVE
To summarize the existing literature for several promising minimally invasive tests to measure disease activity in eosinophilic esophagitis (EoE).
DATA SOURCES
Literature searches were performed using PubMed. Keyword combinations included eosinophilic esophagitis and minimally invasive techniques, including the esophageal string test, Cytosponge, transnasal endoscopy, technetium-labeled heparin, and noninvasive biomarkers.
STUDY SELECTIONS
Retrospective and prospective observational studies, peer-reviewed reviews, and systematic reviews were selected. Data were reviewed and summarized.
RESULTS
Various techniques have been developed in recent years to measure disease activity in EoE without the need for conventional endoscopy. Our review summarizes the data on these techniques, the benefits and limitations, and future directions for implementation in both research and clinical care.
CONCLUSION
Tremendous progress has been made toward developing minimally invasive techniques to measure disease activity in EoE. Each of the techniques mentioned in this review has advantages and disadvantages, and some are closer to widespread use than others.
目的
总结几种有前途的微创检测方法，以评估嗜酸性食管炎（EoE）的疾病活动度。
资料来源
使用 PubMed 进行文献检索。关键词组合包括嗜酸性食管炎和微创技术，包括食管线试验、Cytosponge、经鼻内镜、锝标记肝素和非侵入性生物标志物。
研究选择
选择了回顾性和前瞻性观察研究、同行评议的综述以及系统综述。对数据进行了审查和总结。
结果
近年来，为了在不需要常规内镜的情况下评估 EoE 的疾病活动度，已经开发出了各种技术。我们的综述总结了这些技术的数据、优点和局限性，以及在研究和临床护理中实施的未来方向。
结论
在开发用于评估 EoE 疾病活动度的微创技术方面已经取得了巨大进展。本综述中提到的每种技术都有其优缺点，其中一些技术比其他技术更接近广泛应用。
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