在发育早期家庭内使用农药与成年后患睾丸生殖细胞肿瘤风险：一项法国全国性病例对照研究。
Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study.
机构信息
Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, 150 cours Albert Thomas, 69372, Lyon, Cedex 08, France.
Département Prévention, Cancer et Environnement, Centre Léon Bérard, Lyon, France.
出版信息
Environ Health. 2021 Oct 28;20(1):111. doi: 10.1186/s12940-021-00795-y.
BACKGROUND
Testicular germ cell tumours (TGCT) are the most frequent cancers in young men in developed countries and their incidence rate has doubled worldwide over the past 40 years. Early life exposures to pesticides are suspected to increase TGCT risk. Our research aimed at estimating adult TGCT risk associated with parental domestic use of pesticides during early periods of child development.
METHODS
We conducted a case-control study of 304 TGCT cases, aged 18-45 years old, recruited in 20 French university hospitals, and 274 controls frequency-matched on hospital and birth year. Participants' mothers provided information on their domestic use of pesticides from 1 year before start of pregnancy to 1 year after their son's birth, for gardening activities, treatment of indoor plants, pets, wood and mold, and pest control. Odds ratios (OR) for TGCT (overall and by histological subtype) and 95% confidence intervals (CI) were estimated using conditional logistic regression.
RESULTS
Prevalence of reported domestic use of pesticides was 77.3% for insecticides, 15.9% for fungicides and 12.1% for herbicides. While no association was found for any use of insecticides (OR = 1.27, CI = 0.80-2.01) or herbicides (OR = 1.15, CI = 0.67-2.00), elevated risks of TGCT overall (OR = 1.73, CI = 1.04-2.87) and non-seminoma subtype (OR = 2.44, CI = 1.26-4.74) were observed for any use of fungicides. When specific purposes were examined, using fungicides and/or insecticides for woodwork (OR = 2.35, CI = 1.06-5.20) and using insecticides on cats and dogs (OR = 1.95, CI = 1.12-3.40) were associated with increased risk of non-seminoma subtype. We found no association for seminoma subtype.
CONCLUSIONS
Although recall bias may partially explain the elevated ORs, our study provides some evidence of a positive association between domestic use of pesticides during early periods of development, particularly fungicides and risk of adult TGCT and non-seminoma. Given the common domestic use of pesticides in France, further research on TGCT risk is warranted.
背景
在发达国家，睾丸生殖细胞肿瘤（TGCT）是年轻男性中最常见的癌症，在过去的 40 年中，其发病率在全球翻了一番。早期生活中接触农药被怀疑会增加 TGCT 的风险。我们的研究旨在估计与儿童发育早期父母家庭使用农药有关的成年 TGCT 风险。
方法
我们进行了一项病例对照研究，纳入了 304 例年龄在 18-45 岁的 TGCT 病例，这些病例均在法国 20 所大学医院招募，274 例对照与医院和出生年份相匹配。参与者的母亲提供了从怀孕前 1 年到儿子出生后 1 年期间，进行园艺活动、室内植物治疗、宠物、木材和霉菌以及害虫防治时家庭使用农药的信息。使用条件逻辑回归估计 TGCT（总体和组织学亚型）和 95%置信区间（CI）的比值比（OR）。
结果
报告的家庭使用杀虫剂的比例为 77.3%，杀菌剂为 15.9%，除草剂为 12.1%。虽然没有发现任何杀虫剂（OR=1.27，CI=0.80-2.01）或除草剂（OR=1.15，CI=0.67-2.00）使用与 TGCT 总体风险相关，但是观察到总体（OR=1.73，CI=1.04-2.87）和非精原细胞瘤（OR=2.44，CI=1.26-4.74）风险增加，使用杀菌剂时。当检查特定用途时，使用杀菌剂和/或杀虫剂进行木制品（OR=2.35，CI=1.06-5.20）和使用杀虫剂处理猫和狗（OR=1.95，CI=1.12-3.40）与非精原细胞瘤的风险增加有关。我们没有发现精原细胞瘤亚型的关联。
结论
尽管回忆偏倚可能部分解释了升高的 OR，但我们的研究提供了一些证据，表明在儿童发育早期家庭使用农药与 TGCT 和非精原细胞瘤的成年发病风险之间存在正相关。鉴于法国普遍使用农药，有必要进一步研究 TGCT 的风险。
Zotero 插件