Department of Rheumatology, Fukushima Medical University School of Medicine.
Department of Dermatology, Fukushima Medical University School of Medicine.
Tohoku J Exp Med. 2021 Oct;255(2):163-169. doi: 10.1620/tjem.255.163.
Behcet's disease is a systemic vasculitis characterized by oral and genital ulcers, erythema nodosum, and ocular involvement. Fever of unknown origin is a relatively rare event in Behcet's disease. We present the case of a 17-year-old male patient who suffered from prolonged fever for two months. The patient tested positive for HLA-B52 and levels of acute phase reactants were elevated. He complained of sore throat and neck pain that were evaluated by cervical ultrasonography, which revealed thickening of the carotid arterial wall and narrowing of the vessel lumen. The patient was diagnosed with vascular Behcet's disease and treated with glucocorticoid, which improved the clinical symptoms and thickening of the carotid arterial wall as detected by color duplex ultrasonography. Since vascular Behcet's disease may lead to morbidity and mortality, we suggest the early use of ultrasonography to help detect medium/large-vessel vasculitis. Prolonged fever in patients with Behcet's disease should be promptly evaluated for vascular involvement.
贝赫切特病是一种系统性血管炎，其特征为口腔和生殖器溃疡、结节性红斑和眼部受累。发热原因不明是贝赫切特病中相对罕见的事件。我们报告了 1 例 17 岁男性患者，其持续发热 2 个月。该患者 HLA-B52 检测阳性，急性期反应物水平升高。他诉咽痛和颈部疼痛，经颈超声检查发现颈动脉壁增厚和血管腔狭窄。该患者被诊断为血管贝赫切特病，并接受糖皮质激素治疗，这改善了临床症状和彩色双功能超声检查发现的颈动脉壁增厚。由于血管贝赫切特病可能导致发病率和死亡率，我们建议早期使用超声检查来帮助检测中/大血管血管炎。贝赫切特病患者的长期发热应及时评估血管受累情况。
