Department of Surgical Oncology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Department of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia.
Front Endocrinol (Lausanne). 2021 Oct 11;12:745236. doi: 10.3389/fendo.2021.745236. eCollection 2021.
This study aims to evaluate the association and dose-response between triglyceride-glucose (TyG) index and breast cancer.
This is a multicenter case-control study conducted in six public referral hospitals in Indonesia. Cases are individuals aged 19 years or above who were diagnosed with breast cancer within 1 year of diagnosis, based on histopathology and immunohistochemistry. Controls were recruited from corresponding hospitals. TyG index was determined by the formula: ln (fasting TG [mg/dl] × fasting glucose [mg/dl]).
There were 212 participants in the breast cancer group and 212 participants in the control group. TyG index was higher in patients with breast cancer (median 8.65 [7.38, 10.9] vs. 8.30 [7.09, 10.84], < 0.001). When compared with TyG quartile of Q1, Q4 was associated with an OR of 2.42 (1.77, 3.31), < 0.001, Q3 was associated with an OR of 1.53 (1.21, 1.93), < 0.001, Q2 was associated with an OR of 1.39 (1.12, 1.73), = 0.002 for the risk of breast cancer. The dose-response relationship was nonlinear ( < 0.001). On univariate analysis, smoking (OR 2.15 [1.44, 3.22], < 0.001), use of contraception (1.73 [1.15, 2.60], = 0.008), alcohol consumption (OR 2.04 [0.96, 4.35], = 0.064), and TyG Index >8.87 (OR 3.08 [1.93, 4.93], < 0.001) were associated with risk of breast cancer. Independently associated with increased risk of breast cancer included smoking (OR 1.93 [1.23, 3.01], = 0.004), use of contraception (OR 1.59 [1.02, 2.48], = 0.039), and TyG Index >8.87 (OR 2.93 [1.72, 4.98], < 0.001).
TyG index was associated with breast cancer in a nonlinear dose-response fashion.
本研究旨在评估甘油三酯-葡萄糖（TyG）指数与乳腺癌之间的关联和剂量反应关系。
这是一项在印度尼西亚六家公立医院进行的多中心病例对照研究。病例为 19 岁及以上、经组织病理学和免疫组织化学检查确诊为乳腺癌的个体。对照组从相应的医院招募。TyG 指数通过公式：ln（空腹 TG [mg/dl]×空腹血糖 [mg/dl]）确定。
乳腺癌组有 212 名参与者，对照组有 212 名参与者。乳腺癌患者的 TyG 指数较高（中位数 8.65[7.38, 10.9]比 8.30[7.09, 10.84]，<0.001）。与 TyG 四分位 Q1 相比，Q4 与 OR 2.42（1.77, 3.31）相关，<0.001，Q3 与 OR 1.53（1.21, 1.93）相关，<0.001，Q2 与 OR 1.39（1.12, 1.73）相关，=0.002 与乳腺癌风险相关。剂量反应关系呈非线性（<0.001）。在单因素分析中，吸烟（OR 2.15[1.44, 3.22]，<0.001）、使用避孕药（OR 1.73[1.15, 2.60]，=0.008）、饮酒（OR 2.04[0.96, 4.35]，=0.064）和 TyG 指数>8.87（OR 3.08[1.93, 4.93]，<0.001）与乳腺癌风险相关。与乳腺癌风险增加独立相关的因素包括吸烟（OR 1.93[1.23, 3.01]，=0.004）、使用避孕药（OR 1.59[1.02, 2.48]，=0.039）和 TyG 指数>8.87（OR 2.93[1.72, 4.98]，<0.001）。
TyG 指数与乳腺癌呈非线性剂量反应关系。
