Ge Peng, Luo Yalan, Chen Haiyang, Liu Jiayue, Guo Haoya, Xu Caiming, Qu Jialin, Zhang Guixin, Chen Hailong
Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, China.
Front Oncol. 2021 Oct 11;11:667427. doi: 10.3389/fonc.2021.667427. eCollection 2021.
Pancreatic cancer (PC) is one of the most common malignant tumors in the digestive tract worldwide, with increased morbidity and mortality. In recent years, with the development of surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, and the change of the medical thinking model, remarkable progress has been made in researching comprehensive diagnosis and treatment of PC. However, the present situation of diagnostic and treatment of PC is still unsatisfactory. There is an urgent need for academia to fully integrate the basic research and clinical data from PC to form a research model conducive to clinical translation and promote the proper treatment of PC. This paper summarized the translation progress of mass spectrometry (MS) in the pathogenesis, diagnosis, prognosis, and PC treatment to promote the basic research results of PC into clinical diagnosis and treatment.
胰腺癌（PC）是全球消化道最常见的恶性肿瘤之一，其发病率和死亡率呈上升趋势。近年来，随着手术、化疗、放疗、靶向治疗和免疫治疗的发展，以及医学思维模式的转变，胰腺癌综合诊疗研究取得了显著进展。然而，胰腺癌的诊疗现状仍不尽人意。学术界迫切需要充分整合胰腺癌的基础研究和临床数据，形成有利于临床转化的研究模式，推动胰腺癌的合理治疗。本文综述了质谱（MS）在胰腺癌发病机制、诊断、预后及治疗方面的转化进展，以促进胰腺癌基础研究成果向临床诊疗转化。
