Blum Kenneth, Atzmon Gil, Baron David, Badgaiyan R D
Departments of Psychiatry and Behavioural Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA USA.
Department of Psychiatry, Wright State University Boonshoft School of Medicine and Dayton VA Medical Center, Dayton, OH (IE).
SOJ Psychol. 2016 Oct 17;3(2):1-5. doi: 10.15226/2374-6874/3/2/00129.
Numerous studies indicated that the prevalence of certain alleles of the dopamine D2 receptor gene () vary across different ethnic groups. Under adverse environmental conditions, these alleles can increase the risk of developing psychiatric symptoms. Thus, we hypothesized that the prevalence of the gene allele may serve to explain the horrific behaviours practiced by the Nazi regime. Hitler's 'Brain Washing' methods goaded his followers to carry out genocide at a time when carriers of the allele (the so called 'aggressive--genotype') were significantly higher among the Aryan Germans compared to resident German Jews. It would be of interest, to genotype the Jewish Holocaust survivors, to determine whether those with the allele survived in greater numbers. The hypothesis being that, greater survival may result in enhanced frequency of not only the allele but other reward gene polymorphisms among survivors. Understanding the molecular genetics of any population in terms of reward dependence and subsequent behaviours will be most beneficial in future human interaction whether negative (war) or positive (peace) in nature.
许多研究表明，多巴胺D2受体基因（）某些等位基因的流行率在不同种族群体中有所不同。在不利的环境条件下，这些等位基因会增加出现精神症状的风险。因此，我们推测该基因等位基因的流行率可能有助于解释纳粹政权实施的恐怖行为。希特勒的“洗脑”方法驱使他的追随者进行种族灭绝，而在那个时候，与德国犹太居民相比，雅利安德国人中该等位基因（所谓的“攻击性——基因型”）的携带者比例要高得多。对犹太大屠杀幸存者进行基因分型，以确定携带该等位基因的人是否有更多人幸存下来，这将是很有意思的。假设是，更高的存活率可能不仅会导致该等位基因频率增加，还会导致幸存者中其他奖励基因多态性增加。从奖励依赖和后续行为的角度理解任何人群的分子遗传学，无论是在消极（战争）还是积极（和平）性质的未来人类互动中，都将非常有益。
