Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716, United States.
Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, United States.
Chem Rev. 2021 Nov 24;121(22):13915-13935. doi: 10.1021/acs.chemrev.1c00712. Epub 2021 Oct 28.
Peptides have been extensively utilized to construct nanomaterials that display targeted structure through hierarchical assembly. The self-assembly of both rationally designed peptides derived from naturally occurring domains in proteins as well as intuitively or computationally designed peptides that form β-sheets and helical secondary structures have been widely successful in constructing nanoscale morphologies with well-defined 1-d, 2-d, and 3-d architectures. In this review, we discuss these successes of peptide self-assembly, especially in the context of designing hierarchical materials. In particular, we emphasize the differences in the level of peptide design as an indicator of complexity within the targeted self-assembled materials and highlight future avenues for scientific and technological advances in this field.
肽已被广泛用于构建通过分级组装显示靶向结构的纳米材料。通过合理设计源自蛋白质中天然结构域的肽以及直观或计算设计形成β-折叠和螺旋二级结构的肽的自组装，已经广泛成功地构建了具有明确定义的 1-D、2-D 和 3-D 结构的纳米级形态。在这篇综述中，我们讨论了肽自组装的这些成功，特别是在设计分级材料方面。特别是，我们强调了肽设计水平的差异，以此作为目标自组装材料复杂性的指标，并强调了该领域科学技术进步的未来方向。
