Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona.
Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Behav Brain Res. 2022 Feb 10;418:113634. doi: 10.1016/j.bbr.2021.113634. Epub 2021 Oct 25.
Most people have a soundtrack of life, a set of special musical pieces closely linked to certain biographical experiences. Autobiographical memories (AM) and music listening (ML) involve complex mental processes ruled by differentiate brain networks. The aim of the paper was to determine the way both networks interact in linked occurrences. We performed an fMRI experiment on 31 healthy participants (age: 32.4 ± 7.6, 11 men, 4 left-handers). Participants had to recall AMs prompted by music they reported to be associated with personal biographical events (LMM: linked AM-ML events). In the main control task, participants were prompted to recall emotional AMs while listening known tracks from a pool of popular music (UMM: unlinked AM-ML events). We wanted to investigate to what extent LMM network exceeded the overlap of AM and ML networks by contrasting the activation obtained in LMM versus UMM. The contrast LMM>UMM showed the areas (at P < 0.05 FWE corrected at voxel level and cluster size>20): right frontal inferior operculum, frontal middle gyrus, pars triangularis of inferior frontal gyrus, occipital superior gyrus and bilateral basal ganglia (caudate, putamen and pallidum), occipital (middle and inferior), parietal (inferior and superior), precentral and cerebellum (6, 7 L, 8 and vermis 6 and 7). Complementary results were obtained from additional control tasks. Provided part of tLMM>UMM areas might not be related to ML-AM linkage, we assessed LMM brain network by an independent component analysis (ICA) on contrast images. Results from ICA suggest the existence of a cortico-ponto-cerebellar network including left precuneus, bilateral anterior cingulum, parahippocampal gyri, frontal inferior operculum, ventral anterior part of the insula, frontal medial orbital gyri, caudate nuclei, cerebellum 6 and vermis, which might rule the ML-induced retrieval of AM in closely linked AM-ML events. This topography may suggest that the pathway by which ML is linked to AM is attentional and directly related to perceptual processing, involving salience network, instead of the natural way of remembering typically associated with default mode network.
大多数人都有自己的人生配乐，即一组与特定生平经历密切相关的特殊乐曲。自传体记忆（AM）和音乐聆听（ML）涉及由差异化的大脑网络所支配的复杂心理过程。本文旨在确定这两个网络在关联事件中相互作用的方式。我们对 31 名健康参与者（年龄：32.4±7.6，11 名男性，4 名左撇子）进行了 fMRI 实验。参与者必须在音乐提示下回忆与个人生平事件相关的 AM（LMM：关联的 AM-ML 事件）。在主要的对照任务中，参与者在聆听已知流行音乐曲目的同时，被提示回忆情绪 AM（UMM：不关联的 AM-ML 事件）。我们希望通过比较 LMM 与 UMM 中的激活情况，来探究 LMM 网络在多大程度上超出了 AM 和 ML 网络的重叠。与 UMM 相比，LMM 激活的区域（在 P<0.05 时的 FWE 校正体素水平和簇大小>20）：右侧额下回、额中回、额下回三角部、顶叶上回和双侧基底节（尾状核、壳核和苍白球）、枕叶（中回和下回）、顶叶（下回和上回）、中央前回和小脑（6、7L、8 和蚓部 6 和 7）。从额外的对照任务中获得了补充结果。鉴于 LMM 与 UMM 相比的部分激活区域可能与 ML-AM 关联无关，我们通过对比图像的独立成分分析（ICA）评估了 LMM 网络。ICA 的结果表明，存在一个皮质-桥脑-小脑网络，包括左侧楔前叶、双侧前扣带、海马旁回、额下回、前岛叶腹侧部、额内侧眶回、尾状核、小脑 6 和蚓部，这可能支配 ML 诱发的紧密关联的 AM-ML 事件中的 AM 检索。这种拓扑结构可能表明，ML 与 AM 关联的途径是注意力的，并且与感知处理直接相关，涉及突显网络，而不是与默认模式网络相关联的典型记忆方式。
