Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
The First Clinical Medical College, Nanchang University, Nanchang 330006, China.
J Immunol Res. 2021 Oct 19;2021:1007126. doi: 10.1155/2021/1007126. eCollection 2021.
Acute lung injury (ALI) is an inflammatory disorder of the lung that causes high mortality and lacks any pharmacological intervention. Ubiquitination plays a critical role in the pathogenesis of ALI as it regulates the alveolocapillary barrier and the inflammatory response. Tripartite motif (TRIM) proteins are one of the subfamilies of the RING-type E3 ubiquitin ligases, which contains more than 80 distinct members in humans involved in a broad range of biological processes including antivirus innate immunity, development, and tumorigenesis. Recently, some studies have shown that several members of TRIM family proteins play important regulatory roles in inflammation and ALI. Herein, we integrate emerging evidence regarding the roles of TRIMs in ALI. Articles were selected from the searches of PubMed database that had the terms "acute lung injury," "ubiquitin ligases," "tripartite motif protein," "inflammation," and "ubiquitination" using both MeSH terms and keywords. Better understanding of these mechanisms may ultimately lead to novel therapeutic approaches by targeting TRIMs for ALI treatment.
急性肺损伤（ALI）是一种肺部炎症性疾病，死亡率高，且缺乏任何药物干预手段。泛素化在 ALI 的发病机制中起着关键作用，因为它可以调节肺泡毛细血管屏障和炎症反应。三基序（TRIM）蛋白是 RING 型 E3 泛素连接酶的一个亚家族，在人类中包含 80 多种不同的成员，参与广泛的生物学过程，包括抗病毒固有免疫、发育和肿瘤发生。最近的一些研究表明，TRIM 家族蛋白的几个成员在炎症和 ALI 中发挥着重要的调节作用。在此，我们综合了关于 TRIM 在 ALI 中作用的新出现的证据。使用主题词和关键词，从 PubMed 数据库中检索到包含“acute lung injury”、“ubiquitin ligases”、“tripartite motif protein”、“inflammation”和“ubiquitination”的文章。通过针对 TRIM 治疗 ALI，更好地了解这些机制可能最终会导致新的治疗方法。
