Alavi Matin, Farkhondeh Tahereh, Aschner Michael, Samarghandian Saeed
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Cancer Cell Int. 2021 Oct 30;21(1):579. doi: 10.1186/s12935-021-02280-5.
Cancer represents a major health problem with an exceedingly high toll on the patients, their families, and the economy. Cancers are also associated with high mortality rates. Existing therapies for cancer are generally ineffective with many side effects.
A search was conducted on Pubmed, Google Scholar, Scopus, and web of science databases, and articles related to anticancer effects of resveratrol were collected.
Resveratrol is a natural compound that can activate the Nrf2 transcription factor. Nfr2 translocates to the nucleus and induces antioxidant gene expression. In different cell lines, resveratrol can increase apoptosis and inhibit the proliferation of cancer cells.
We found that resveratrol shows efficacy for the treatment of cancer, but due to high controversy on the Nrf2 signaling pathway and mechanisms of resveratrol action, additional studies should be conducted to better characterize its mode-of-action in cancer.
癌症是一个重大的健康问题，给患者、其家庭及经济带来了极高的代价。癌症还与高死亡率相关。现有的癌症治疗方法通常效果不佳且有许多副作用。
在PubMed、谷歌学术、Scopus和科学网数据库中进行检索，收集与白藜芦醇抗癌作用相关的文章。
白藜芦醇是一种能激活Nrf2转录因子的天然化合物。Nfr2易位至细胞核并诱导抗氧化基因表达。在不同细胞系中，白藜芦醇可增加细胞凋亡并抑制癌细胞增殖。
我们发现白藜芦醇对癌症治疗显示出疗效，但由于Nrf2信号通路及白藜芦醇作用机制存在高度争议，应开展更多研究以更好地表征其在癌症中的作用模式。
