Faiyaz Maryam, Ganayee Mohd Azhardin, Akhtar Salman, Krishnan Saravanan, Flora Bableen, Dogra Deeksha, Jha Niraj Kumar, Chellappan Dinesh Kumar, Negi Poonam, Dua Kamal, Kesari Kavindra Kumar, Gupta Piyush Kumar
Department of Bioengineering, Integral University, Kursi Road, 226026 Lucknow, Uttar Pradesh, India.
Department of Chemistry, Indian Institute of Technology Madras, 600036 Chennai, Tamil Nadu, India.
Front Biosci (Landmark Ed). 2021 Oct 30;26(10):851-865. doi: 10.52586/4992.
Alzheimer's, a progressive neurodegenerative disease affects brain and neurons through enormous reduction in nerve cell regenerative capacity. Dementia and impairment of cognitive functions are more prevalent in Alzheimer's disease (AD) patients in both industrialized and non-industrialized countries. Various factors play significant role in molecular cascades that leads to neuronal inflammation, dementia and thereby AD progression. Current medications are symptomatic that alleviates pain while lack in absolute cure, urging researchers to explore targets and therapeutics. Interestingly, nanomedicines developed due to the onset of nanotechnology, are being extensively investigated for the treatment of AD. This review presents the advancement in nanotherapeutic strategies, involving the emergence of nanomaterials that offers advantage to pass through the blood-brain barrier and acts as a therapeutic modality against AD.
阿尔茨海默病是一种进行性神经退行性疾病，通过神经细胞再生能力的大幅下降影响大脑和神经元。在工业化国家和非工业化国家，痴呆和认知功能障碍在阿尔茨海默病（AD）患者中更为普遍。各种因素在导致神经元炎症、痴呆从而推动AD进展的分子级联反应中发挥着重要作用。目前的药物只是缓解症状，缺乏绝对的治愈方法，这促使研究人员探索治疗靶点和疗法。有趣的是，由于纳米技术的出现而开发的纳米药物正在被广泛研究用于治疗AD。本综述介绍了纳米治疗策略的进展，包括纳米材料的出现，这些纳米材料具有穿过血脑屏障的优势，并可作为对抗AD的治疗方式。
