Shanghai Key Laboratory of Lightweight Composite, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P. R. China.
Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P. R. China.
J Mater Chem B. 2021 Nov 24;9(45):9316-9323. doi: 10.1039/d1tb02115j.
Photothermal therapy (PTT) has shown great promise for cancer treatment light-triggered heat generation, while the anticancer efficacy of sole PTT is often limited. In this study, we report the use of radionuclide I-labeled gold nanoframeworks (I-AuNFs) for radiotherapy-combined second near-infrared (NIR-II) PTT of breast cancer. AuNFs synthesized a simple reduction approach are surface functionalized with polydopamine and poly(ethylene glycol), followed by labeling with I. The formed I-AuNFs with a high photothermal conversion efficacy and stable radioactivity can effectively accumulate into subcutaneous 4T1 mouse models as confirmed by single photon emission computed tomography (SPECT) imaging. Upon 1064 nm laser irradiation of tumors, local heat is generated for NIR-II PTT, which combines with radiotherapy to achieve a much higher therapeutic efficacy relative to sole treatment. As such, I-AuNFs-mediated radiotherapy-combined NIR-II PTT results in the effective inhibition of the growth of subcutaneous tumors. This study thus provides a facile nanoplatform for effective combination cancer therapy.
光热疗法（PTT）在癌症治疗方面显示出巨大的应用前景，其原理是光触发产生热量，而单纯的 PTT 抗癌效果往往有限。在这项研究中，我们报告了放射性核素碘标记的金纳米框架（I-AuNFs）在联合放射治疗的近红外二区（NIR-II）光热治疗乳腺癌中的应用。AuNFs 通过简单的还原方法合成，表面功能化有多巴胺和聚乙二醇，然后用碘标记。形成的 I-AuNFs 具有高的光热转换效率和稳定的放射性，通过单光子发射计算机断层扫描（SPECT）成像证实可以有效地在皮下 4T1 小鼠模型中积累。当肿瘤受到 1064nm 激光照射时，会产生用于 NIR-II PTT 的局部热量，与放射治疗相结合，相对于单独治疗，可实现更高的治疗效果。因此，I-AuNFs 介导的放射治疗联合 NIR-II PTT 有效抑制了皮下肿瘤的生长。这项研究因此提供了一种有效的联合癌症治疗的简便纳米平台。
