Liu Yuling, Su Meng, Wang Yinghan, Du Yilong, Wang Yan, Hu Nan
Key Laboratory of Traditional Chinese Medicine Research and Development, Chengde Medical University, Chengde, 067000, China.
Heliyon. 2024 Feb 29;10(5):e27408. doi: 10.1016/j.heliyon.2024.e27408. eCollection 2024 Mar 15.
Although numerous photothermal nanoparticles have been designed to improve the enhanced and permeability and retention (EPR) effect, the delivery of nanoparticles to the tumor site remains a major obstacle in cancer treatment. The interstital structure and its internal fluid that play an important role in material transmission, intercellular signal transduction, tissue morphology, immunity, tumor development, and disease diagnosis and treatment may be considered as a new route for drug delivery. Here, we prepared a nanoplatform composed of polydopamine (PDA), indocyanine green (ICG) as a photothermal agent, and paclitaxel (PTX) as a chemotherapeutic drug. The designed PDA-ICG nanoparticles displayed excellent photothermal conversion ability, with the synergistic effect of PTX, the growth of MDA-MB-231 cells was significantly suppressed with the cell viability of 6.19% . Taking advantage of bioimaging ability of ICG, tumor-targeting of the nanoparticles injected into the interstitial space was study, Compared with intravenous injection, nanoparticles better targeted the tumor based on the interstitial fluid flow in MBA-MD-231 bearing mice. Furthermore, the antitumor efficacy was studied . With the improved accumulation of PDA-ICG-PTX nanoparticles injected into the interstitial space and the synergistic effect of photothermal therapy and chemotherapy, tumor growth was inhibited without obvious side effects. These results demonstrated that interstitial space injection may be a superior administration route for tumor-targeting nanoparticles. The PDA-ICG-PTX nanoparticles delivered via the interstitial space exhibit great potential in the photothermal chemotherapy of cancers.
尽管已经设计了许多光热纳米粒子来改善增强的渗透和滞留（EPR）效应，但纳米粒子向肿瘤部位的递送仍然是癌症治疗中的一个主要障碍。在物质传输、细胞间信号转导、组织形态、免疫、肿瘤发展以及疾病诊断和治疗中起重要作用的间质结构及其内部流体可被视为一种新的药物递送途径。在此，我们制备了一种由聚多巴胺（PDA）、作为光热剂的吲哚菁绿（ICG）和作为化疗药物的紫杉醇（PTX）组成的纳米平台。所设计的PDA-ICG纳米粒子表现出优异的光热转换能力，在PTX的协同作用下，MDA-MB-231细胞的生长受到显著抑制，细胞活力为6.19%。利用ICG的生物成像能力，研究了注入间质空间的纳米粒子的肿瘤靶向性，与静脉注射相比，基于MBA-MD-231荷瘤小鼠的间质液流动，纳米粒子对肿瘤的靶向性更好。此外，还研究了抗肿瘤疗效。随着注入间质空间的PDA-ICG-PTX纳米粒子积累的改善以及光热疗法和化疗的协同作用，肿瘤生长受到抑制且无明显副作用。这些结果表明，间质空间注射可能是肿瘤靶向纳米粒子的一种优越给药途径。通过间质空间递送的PDA-ICG-PTX纳米粒子在癌症的光热化疗中具有巨大潜力。
