Department of Ophthalmology, University of Campinas, Campinas, Brazil.
Acta Ophthalmol. 2014 Jun;92(4):e252-66. doi: 10.1111/aos.12298. Epub 2013 Nov 18.
This review article discusses the relationship between ocular perfusion pressure and glaucoma, including its definition, factors that influence its calculation and epidemiological studies investigating the influence of ocular perfusion pressure on the prevalence, incidence and progression of glaucoma. We also list the possible mechanisms behind this association, and discuss whether it is secondary to changes in intraocular pressure, blood pressure or both. Finally, we describe the circadian variation of ocular perfusion pressure and the effects of systemic and topical medications on it. We believe that the balance between IOP and BP, influenced by the autoregulatory capacity of the eye, is part of what determines whether an individual will develop optic nerve damage. However, prospective, longitudinal studies are needed to better define the role of ocular perfusion pressure in the development and progression of glaucoma.
这篇综述文章讨论了眼灌注压与青光眼之间的关系，包括其定义、影响其计算的因素以及研究眼灌注压对青光眼患病率、发病率和进展影响的流行病学研究。我们还列出了这种关联背后的可能机制，并讨论了它是眼压、血压还是两者变化的结果。最后，我们描述了眼灌注压的昼夜变化以及全身和局部药物对其的影响。我们认为，眼压和血压之间的平衡，受眼睛的自动调节能力影响，是决定个体是否会发生视神经损伤的因素之一。然而，需要前瞻性、纵向研究来更好地确定眼灌注压在青光眼发展和进展中的作用。
