- 阿尔茨海默病中的诱导性神经炎症。
-Induced Neuroinflammation in Alzheimer's Disease.
作者信息
Olsen Ingar
机构信息
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
出版信息
Front Neurosci. 2021 Oct 14;15:691016. doi: 10.3389/fnins.2021.691016. eCollection 2021.
Abstract
"Chronic" periodontitis and its keystone pathogen have repeatedly been associated with Alzheimer's disease (AD). Pathological hallmarks in AD are brain accumulations of amyloid-beta and neurofibrillary tangles consisting of aggregated and hyperphosphorylated tau. In addition, neuroinflammation induced by has increasingly been recognized as a factor in the pathogenesis of AD. The present mini-review discusses possible mechanisms for the induction of neuroinflammation by in AD, involving factors such as pro-inflammatory mediators, amyloid-beta, tau, microglia, cathepsin B, and protein kinase R. Inflammagens of such as lipopolysaccharide and gingipains are also discussed.
摘要
慢性牙周炎及其关键病原体一再被认为与阿尔茨海默病（AD）有关。AD的病理特征是大脑中淀粉样β蛋白的积累以及由聚集和过度磷酸化的tau组成的神经原纤维缠结。此外，由[未提及的因素]诱导的神经炎症越来越被认为是AD发病机制中的一个因素。本综述讨论了[未提及的因素]在AD中诱导神经炎症的可能机制，涉及促炎介质、淀粉样β蛋白、tau、小胶质细胞、组织蛋白酶B和蛋白激酶R等因素。还讨论了[未提及的因素]的炎症原，如脂多糖和牙龈蛋白酶。
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