Zhao Tingting, Pei Lixia, Ning Houxu, Guo Jing, Song Yafang, Zhou Junling, Chen Lu, Sun Jianhua, Mi Zhongping
Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Acupuncture and Moxibustion Disease Project Group of China Evidence-Based Medicine Center of Traditional Chinese Medicine, Nanjing, China.
Front Hum Neurosci. 2021 Oct 14;15:736512. doi: 10.3389/fnhum.2021.736512. eCollection 2021.
Irritable Bowel Syndrome (IBS), as a functional gastrointestinal disorder, is characterized by abdominal pain and distension. Recent studies have shown that acupuncture treatment improves symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D) by altering networks in certain brain regions. However, few studies have used resting-state functional magnetic resonance imaging (fMRI) to compare altered resting-state inter-network functional connectivity in IBS-D patients before and after acupuncture treatment. To analyze altered resting-state inter-network functional connectivity in IBS-D patients before and after acupuncture treatment. A total of 74 patients with IBS-D and 31 healthy controls (HCs) were recruited for this study. fMRI examination was performed in patients with IBS-D before and after acupuncture treatment, but only at baseline in HCs. Data on the left frontoparietal network (LFPN), default mode network (DMN), salience network (SN), ventral attention network (VAN), auditory network (AN), visual network (VN), sensorimotor network (SMN), dorsal attention network (DAN), and right frontoparietal network (RFPN) were subjected to independent component analysis (ICA). The functional connectivity values of inter-network were explored. Acupuncture decreased irritable bowel syndrome symptom severity score (IBS-SSS) and Hamilton Anxiety Scale (HAMA). It also ameliorated symptoms related to IBS-D. Notably, functional connectivity between AN and VAN, SMN and DMN, RFPN and VAN in IBS-D patients after acupuncture treatment was different from that in HCs. Furthermore, there were differences in functional connectivity between DMN and DAN, DAN and LFPN, DMN and VAN before and after acupuncture treatment. The inter-network changes in DMN-VAN were positively correlated with changes in HAMA, life influence degree, and IBS-SSS in IBS-D. Altered inter-network functional connectivity is involved in several important hubs in large-scale networks. These networks are altered by acupuncture stimulation in patients with IBS-D.
肠易激综合征（IBS）作为一种功能性胃肠疾病，其特征为腹痛和腹胀。近期研究表明，针刺治疗可通过改变特定脑区的神经网络来改善腹泻型肠易激综合征（IBS-D）的症状。然而，很少有研究使用静息态功能磁共振成像（fMRI）来比较IBS-D患者针刺治疗前后静息态网络间功能连接的变化。为分析IBS-D患者针刺治疗前后静息态网络间功能连接的变化。本研究共招募了74例IBS-D患者和31名健康对照者（HCs）。对IBS-D患者针刺治疗前后进行了fMRI检查，而HCs仅在基线时进行检查。对左侧额顶叶网络（LFPN）、默认模式网络（DMN）、突显网络（SN）、腹侧注意网络（VAN）、听觉网络（AN）、视觉网络（VN）、感觉运动网络（SMN）、背侧注意网络（DAN）和右侧额顶叶网络（RFPN）的数据进行独立成分分析（ICA）。探索网络间的功能连接值。针刺降低了肠易激综合征症状严重程度评分（IBS-SSS）和汉密尔顿焦虑量表（HAMA）。它还改善了与IBS-D相关的症状。值得注意的是，针刺治疗后IBS-D患者中AN与VAN、SMN与DMN、RFPN与VAN之间的功能连接与HCs不同。此外，针刺治疗前后DMN与DAN、DAN与LFPN、DMN与VAN之间的功能连接存在差异。IBS-D中DMN-VAN的网络间变化与HAMA、生活影响程度和IBS-SSS的变化呈正相关。网络间功能连接的改变涉及大规模网络中的几个重要枢纽。这些网络在IBS-D患者中通过针刺刺激而发生改变。
