Ourry Valentin, Marchant Natalie L, Schild Ann-Katrin, Coll-Padros Nina, Klimecki Olga M, Krolak-Salmon Pierre, Goldet Karine, Reyrolle Leslie, Bachelet Romain, Sannemann Lena, Meiberth Dix, Demnitz-King Harriet, Whitfield Tim, Botton Maëlle, Lebahar Julie, Gonneaud Julie, de Flores Robin, Molinuevo José Luis, Jessen Frank, Vivien Denis, de la Sayette Vincent, Valenzuela Michael J, Rauchs Géraldine, Wirth Miranka, Chételat Gaël, Arenaza-Urquijo Eider M
Normandie University, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain @ Caen-Normandie, Caen, France.
Normandie University, UNICAEN, PSL Université, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, France.
Front Aging Neurosci. 2021 Oct 14;13:740005. doi: 10.3389/fnagi.2021.740005. eCollection 2021.
The Lifetime of Experiences Questionnaire (LEQ) assesses complex mental activity across the life-course and has been associated with brain and cognitive health. The different education systems and occupation classifications across countries represent a challenge for international comparisons. The objectives of this study were four-fold: to adapt and harmonise the LEQ across four European countries, assess its validity across countries, explore its association with brain and cognition and begin to investigate between-country differences in life-course mental activities. The LEQ was administered to 359 cognitively unimpaired older adults (mean age and education: 71.2, 13.2 years) from IMAP and EU-funded Medit-Ageing projects. Education systems, classification of occupations and scoring guidelines were adapted to allow comparisons between France, Germany, Spain and United Kingdom. We assessed the LEQ's (i) concurrent validity with a similar instrument (cognitive activities questionnaire - CAQ) and its structural validity by testing the factors' structure across countries, (ii) we investigated its association with cognition and neuroimaging, and (iii) compared its scores between countries. The LEQ showed moderate to strong positive associations with the CAQ and revealed a stable multidimensional structure across countries that was similar to the original LEQ. The LEQ was positively associated with global cognition. Between-country differences were observed in leisure activities across the life-course. The LEQ is a promising tool for assessing the multidimensional construct of cognitive reserve and can be used to measure socio-behavioural determinants of cognitive reserve in older adults across countries. Longitudinal studies are warranted to test further its clinical utility.
《一生经历问卷》（LEQ）评估了整个生命历程中的复杂心理活动，并且与大脑和认知健康相关。各国不同的教育体系和职业分类给国际比较带来了挑战。本研究的目标有四个：在四个欧洲国家对LEQ进行改编和统一，评估其在各国的有效性，探究其与大脑和认知的关联，并开始调查各国在生命历程心理活动方面的差异。LEQ被施用于来自IMAP和欧盟资助的Medit-Ageing项目的359名认知未受损的老年人（平均年龄和受教育年限：71.2岁，13.2年）。对教育体系、职业分类和评分指南进行了调整，以便在法国、德国、西班牙和英国之间进行比较。我们评估了LEQ的（i）与类似工具（认知活动问卷 - CAQ）的同时效度，以及通过测试各国的因素结构来评估其结构效度，（ii）我们研究了它与认知和神经影像学的关联，以及（iii）比较了各国之间的得分。LEQ与CAQ显示出中度到强的正相关，并揭示了各国之间稳定的多维结构，这与原始的LEQ相似。LEQ与整体认知呈正相关。在生命历程的休闲活动方面观察到了各国之间的差异。LEQ是评估认知储备多维结构的一个有前景的工具，可用于衡量各国老年人认知储备的社会行为决定因素。有必要进行纵向研究以进一步测试其临床效用。
