The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
Department of Proctology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
Comput Math Methods Med. 2021 Oct 21;2021:1016108. doi: 10.1155/2021/1016108. eCollection 2021.
To unearth the clinical efficacy of tacrolimus ointment + 3% boric acid lotion joint Chinese angelica decoction in chronic perianal eczema.
Patients with chronic perianal eczema admitted to hospital from June 2018 and June 2019 were retrospectively analyzed. Patients in the control group ( = 38) underwent basic therapy with tacrolimus ointment + 3% boric acid lotion, whereas those in the observation group ( = 38) were given oral Chinese angelica decoction on the basis of the above therapy. Patient's baseline information before therapy and clinical symptoms after therapy were observed and compared, including pruritus ani score, anus drainage and damp score, skin lesion score, skin lesion area score, life quality index score, and IL-2, IL-4, and IgE levels in serum. Overall efficacy in the two groups was also evaluated.
No significant differences were found in the baseline information between the observation group and control group before therapy. After therapy, pruritus ani score ( = 0.023), anus drainage and damp score ( = 0.041), skin lesion score ( = 0.025), and skin lesion area score ( = 0.035) of patients in the observation group were remarkably lower than those in the control group. Significantly higher release levels of clinical symptoms of patients in the observation group were indicated. With respect to the control group, the life quality score ( = 0.020) and IgE level in serum ( = 0.003) of patients in the observation group were significantly lower, while IL-4 level in serum was significantly higher ( = 0.129). The therapy in the observation group achieved better clinical efficacy. Overall efficacy in the observation group was markedly favorable with respect to the control group.
With respect to tacrolimus ointment + 3% boric acid lotion, patients with chronic perianal eczema displayed better clinical efficacy after jointly being treated by Chinese angelica decoction.
挖掘他克莫司软膏+3%硼酸洗液联合当归饮子治疗慢性肛周湿疹的临床疗效。
回顾性分析 2018 年 6 月至 2019 年 6 月我院收治的慢性肛周湿疹患者，对照组（n=38）给予他克莫司软膏+3%硼酸洗液基础治疗，观察组（n=38）在上述治疗基础上给予当归饮子口服，观察并比较两组患者治疗前的基线资料和治疗后的临床症状，包括肛门瘙痒评分、肛门渗液潮湿评分、皮损评分、皮损面积评分、生活质量指数评分及血清中白细胞介素-2（IL-2）、白细胞介素-4（IL-4）和免疫球蛋白 E（IgE）水平，同时评价两组患者的整体疗效。
观察组与对照组患者治疗前的基线资料比较，差异无统计学意义；治疗后观察组患者的肛门瘙痒评分（t=0.023）、肛门渗液潮湿评分（t=0.041）、皮损评分（t=0.025）和皮损面积评分（t=0.035）均显著低于对照组，表明观察组患者的临床症状缓解程度更高；观察组患者的生活质量评分（t=0.020）和血清 IgE 水平（t=0.003）显著低于对照组，而血清 IL-4 水平（t=0.129）显著高于对照组，观察组患者的血清炎症因子水平改善情况更明显；观察组患者的整体疗效显著优于对照组。
相较于他克莫司软膏+3%硼酸洗液，慢性肛周湿疹患者联合当归饮子治疗后临床疗效更佳。
