Golan Maureen S, Mahoney Emerson, Trump Benjamin, Linkov Igor
U.S. Army Engineer Research and Development Center, Vicksburg, MS, United States.
Curr Opin Chem Eng. 2021 Dec;34:100759. doi: 10.1016/j.coche.2021.100759. Epub 2021 Oct 27.
Nanotechnology facilitated the development and scalable commercialization of many SARS-CoV-2 vaccines. However, the supply chains underpinning vaccine manufacturing have demonstrated brittleness at various stages of development and distribution. Whereas such brittleness leaves the broader pharmacological supply chain vulnerable to significant and unacceptable disruption, strategies for supply chain resilience are being considered across government, academia, and industry. How such resilience is understood and parameterized, however, is contentious. Our review of the nanotechnology supply chain resilience literature, synthesized with the larger supply chain resilience literature, analyzes current trends in implementing and modeling resilience and recommendations for bridging the gap in the lack of quantitative models, consistent definitions, and trade-off analyses for nano supply chains.
纳米技术推动了许多严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗的研发及可扩展的商业化。然而，支撑疫苗生产的供应链在开发和分销的各个阶段都表现出脆弱性。鉴于这种脆弱性使更广泛的药理供应链容易受到重大且不可接受的干扰，政府、学术界和行业正在考虑提高供应链弹性的策略。然而，如何理解和参数化这种弹性存在争议。我们对纳米技术供应链弹性文献的综述，结合更广泛的供应链弹性文献，分析了实施和建模弹性的当前趋势，以及弥合纳米供应链缺乏定量模型、统一定义和权衡分析方面差距的建议。
