乳腺癌手术时间（TTS）与生存率的关系：一项系统评价和荟萃分析
The Relationship between Time to Surgery (TTS) and Survival in Breast Cancer: A Systematic Review and Meta-Analysis.
作者信息
Su Yongcheng, Zheng Xiaogang, Ouyang Zhong
机构信息
Department of Breast Surgery, The First Affiliated Hospital of Xiamen University, Xiamen Fujian 361003, China.
出版信息
Iran J Public Health. 2021 Sep;50(9):1773-1782. doi: 10.18502/ijph.v50i9.7048.
BACKGROUND
Curative operation is the practical and primary therapy for masses of breast cancers. In contrast, the correlation between the time interval from breast cancer diagnosis to curative surgery and survival is still uncertain.
METHODS
An electronic literature search was conducted on PubMed/Medline and EMBASE (between Jan 2000 and Jan 2020). Primary endpoints were overall survival (OS) or Disease-Free Survival (DFS). The HR with 95% confidence intervals were calculated using a random-effects or fixed-effects model.
RESULTS
The combined HR for OS was 1. 10 (95% CI 1. 08-1. 11; =0. 000) by fixed-effects model, no statistically significant heterogeneity was found (=1. 000; I2=0%), and this difference was statistically significant (Z=11. 99; =0. 000).
CONCLUSION
This meta-analysis showed a significant adverse association between more prolonged time to surgery (TTS) and lower overall survival in patients with breast cancer. It is reasonable to minimize that interval between diagnosis and curative surgery.
背景
根治性手术是乳腺癌肿块的主要治疗方法。相比之下，从乳腺癌诊断到根治性手术的时间间隔与生存率之间的相关性仍不确定。
方法
在PubMed/Medline和EMBASE上进行电子文献检索（2000年1月至2020年1月）。主要终点是总生存期（OS）或无病生存期（DFS）。使用随机效应或固定效应模型计算95%置信区间的风险比（HR）。
结果
固定效应模型得出的OS合并HR为1.10（95%CI 1.08 - 1.11；P = 0.000），未发现统计学上的显著异质性（P = 1.000；I² = 0%），且这种差异具有统计学意义（Z = 11.99；P = 0.000）。
结论
这项荟萃分析表明，乳腺癌患者手术时间延长（TTS）与较低的总生存期之间存在显著的负相关。尽量缩短诊断与根治性手术之间的间隔是合理的。
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