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抗 SARS-CoV-2 抗体的最新进展及未来应用方向:NIH 新冠肺炎治疗和预防峰会。

Update on and Future Directions for Use of Anti-SARS-CoV-2 Antibodies: National Institutes of Health Summit on Treatment and Prevention of COVID-19.

机构信息

Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (C.B.).

Office of the Director, National Institutes of Health, Bethesda, Maryland (R.W.E., J.M.A., F.S.C.).

出版信息

Ann Intern Med. 2022 Jan;175(1):119-126. doi: 10.7326/M21-3669. Epub 2021 Nov 2.

Abstract

As the fourth wave of the SARS-CoV-2 pandemic encircles the globe, there remains an urgent challenge to identify safe and effective treatment and prevention strategies that can be implemented in a range of health care and clinical settings. Substantial advances have been made in the use of anti-SARS-CoV-2 antibodies to mitigate the morbidity and mortality associated with COVID-19. On 15 June 2021, the National Institutes of Health, in collaboration with the U.S. Food and Drug Administration, convened a virtual summit to summarize existing knowledge on anti-SARS-CoV-2 antibodies and to identify key unanswered scientific questions to further catalyze the clinical development and implementation of antibodies.

摘要

随着 SARS-CoV-2 疫情的第四波在全球范围内蔓延,仍然迫切需要确定安全有效的治疗和预防策略,可以在各种医疗保健和临床环境中实施。在使用抗 SARS-CoV-2 抗体减轻与 COVID-19 相关的发病率和死亡率方面已经取得了重大进展。2021 年 6 月 15 日,美国国立卫生研究院与美国食品和药物管理局合作,召开了一次虚拟峰会,总结了关于抗 SARS-CoV-2 抗体的现有知识,并确定了关键的未解答科学问题,以进一步促进抗体的临床开发和应用。

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