Harvard/MGH Center on Genomics, Vulnerable Populations & Health Disparities, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Harvard Medical School, Boston, MA 02114, USA.
Epigenomics. 2021 Nov;13(21):1711-1734. doi: 10.2217/epi-2021-0275. Epub 2021 Nov 2.
Few epigenetics studies have been conducted within the Black community to examine the impact of diverse psychosocial stressors and resources for resiliency on the stress pathway (hypothalamus-pituitary-adrenal axis). Among 1000 participants from the Black Women's Health Study, associations between ten psychosocial stressors and DNA methylation (DNAm) of four stress-related genes ( and ) were tested. Whether religiosity or spirituality (R/S) significantly modified these stress-DNAm associations was also assessed. Associations were found for several stressors with DNAm of individual CpG loci and average DNAm levels across each gene, but no associations remained significant after false discovery rate (FDR) correction. Several R/S variables appeared to modify the relationship between two stressors and DNAm, but no identified interaction remained significant after FDR correction. There is limited evidence for a strong signal between stress and DNAm of hypothalamus-pituitary-adrenal axis genes in this general population cohort of US Black women.
鲜有针对黑人社区的表观遗传学研究，来考察多样化的心理社会应激源和适应力资源对压力途径（下丘脑-垂体-肾上腺轴）的影响。在黑人妇女健康研究的 1000 名参与者中，检验了十个心理社会应激源与四个应激相关基因（和）的 DNA 甲基化（DNAm）之间的关联。还评估了宗教信仰或精神信仰（R/S）是否显著改变了这些应激-DNAm 关联。发现了一些与单个 CpG 位点的 DNAm 和每个基因的平均 DNAm 水平相关的应激因素的关联，但在经过错误发现率（FDR）校正后，没有关联仍然具有统计学意义。一些 R/S 变量似乎改变了两个应激源与 DNAm 之间的关系，但在 FDR 校正后，没有鉴定出的相互作用仍然具有统计学意义。在这个美国黑人女性的一般人群队列中，关于应激和下丘脑-垂体-肾上腺轴基因的 DNAm 之间存在强信号的证据有限。
