Key Laboratory of Major Diseases in Children, Ministry of Education, National Key Discipline of Pediatrics, Laboratory of Microbiology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Hum Vaccin Immunother. 2021 Dec 2;17(12):5628-5637. doi: 10.1080/21645515.2021.1985353. Epub 2021 Nov 2.
The universal administration of pneumococcal conjugate vaccines (PCVs) had been demonstrated as an effective way to prevent infection. However, the immunity induced by PCVs protected against the infections caused by vaccine serotypes, which were usually more frequent than non-vaccine serotypes (NVTs). The prevalence and pathogenicity of NVTs after universal vaccination have caused widespread concern. We reviewed the epidemiology of non-PCV13 e before and after PCV13 introduction, and explored the potential reasons for the spread of NVTs. Emerging and spreading NVTs can be regarded as the focus for future serotype epidemiological survey and vaccine optimization.IPD: invasive pneumococcal disease PCV: pneumococcal conjugate vaccines VT: vaccine serotypeNVT: non-vaccine serotype.
通用型肺炎球菌结合疫苗（PCV）的应用已被证实为预防感染的有效方法。然而，PCV 所诱导的免疫仅能针对疫苗血清型引起的感染提供保护，而这些血清型通常比非疫苗血清型（NVTs）更为常见。PCV 广泛应用后，NVTs 的流行率和致病性引起了广泛关注。我们对 PCV13 引入前后非-PCV13 型的流行病学进行了综述，并探讨了 NVTs 传播的潜在原因。新兴和传播的 NVTs 可被视为未来血清型流行病学调查和疫苗优化的重点。IPD：侵袭性肺炎球菌病 PCV：肺炎球菌结合疫苗 VT：疫苗血清型 NVT：非疫苗血清型
