Gupta Manish Kumar, Sansare Vipul, Shrivastava Birendra, Jadhav Santosh, Gurav Prashant
School of Pharmaceutical Sciences, Jaipur National University, Jaipur, India.
Department of Pharmaceutical Chemistry, SVPM'S College of Pharmacy, Malegaon, India.
J Liposome Res. 2022 Sep;32(3):211-223. doi: 10.1080/08982104.2021.1968430. Epub 2021 Nov 2.
Plant-derived phytoconstituents are well known for their therapeutic potential. It has been experimentally demonstrated that whole-plant extract or isolated phytoconstituents reveal various therapeutic potentials like hepatoprotective, antimicrobial, neuroprotective, antitumor, antioxidant, skin protectives, etc. Although these phytoconstituents have potential therapeutic benefits, their use is limited due to their poor bioavailability, stability in biological fluids, and authentication issues. These continue to be an open problem that affects the application of these valuable ancient herbal herbs in the effective treatment and management of various disease conditions. A potential solution to these difficult problems could be the loading of phytoactives in phospholipid-based vesicular systems. Phospholipid-based vesicles like liposomes, phytosomes, ethosomes as well as transfersomes were effectively utilized recently to solve drawbacks and for effective delivery of phytoactives. Several landmark studies observed better therapeutic efficacy of phytoactive loaded vesicles compared to conventional drug delivery. Thus phospholipid-based vesicles mediated phytoactive delivery is a recently developed promising and attractive strategy for better therapeutic control on disease conditions. The present short review highlights recent advances in herbal bioactive loaded phospholipid-based vesicles.
植物来源的植物成分因其治疗潜力而闻名。实验证明，全植物提取物或分离出的植物成分具有多种治疗潜力，如保肝、抗菌、神经保护、抗肿瘤、抗氧化、皮肤保护等。尽管这些植物成分具有潜在的治疗益处，但由于其生物利用度差、在生物流体中的稳定性以及鉴定问题，其应用受到限制。这些仍然是一个悬而未决的问题，影响了这些珍贵的古老草药在各种疾病的有效治疗和管理中的应用。解决这些难题的一个潜在方法可能是将植物活性成分负载到基于磷脂的囊泡系统中。最近有效地利用了基于磷脂的囊泡，如脂质体、植物体、醇质体以及传递体，来解决缺点并有效地递送植物活性成分。几项具有里程碑意义的研究观察到，与传统药物递送相比，负载植物活性成分的囊泡具有更好的治疗效果。因此，基于磷脂的囊泡介导的植物活性成分递送是一种最近开发的、有前景且有吸引力的策略，用于更好地控制疾病状况。本简短综述重点介绍了负载草药生物活性成分的基于磷脂囊泡的最新进展。
