Internal Medicine-Oncology, Hangzhou Cancer Hospital, Hangzhou, China.
Key Laboratory of Image Information Processing and Intelligent Control, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan, 430074, China.
Sci Rep. 2021 Nov 2;11(1):21491. doi: 10.1038/s41598-021-00410-7.
Increasing evidence has demonstrated that lncRNAs are critical regulators in diverse biological processes, but the function of lncRNA in metabolic regulation remains largely unexplored. In this study, we evaluated the association between lncRNA and metabolic pathways and identified metabolism-related lncRNAs. Gastric cancer can be mainly subdivided into 2 clusters based on these metabolism-related lncRNA regulators. Comparative analysis shows that these subtypes are found to be highly consistent with previously identified subtypes based on other omics data. Functional enrichment analysis shows that they are enriched in distinct biological processes. Mutation analysis shows that ABCA13 is a protective factor in subtype C1 but a risk factor in C2. Analysis of chemotherapeutic and immunotherapeutic sensitivity shows that these subtypes tend to display distinct sensitivity to the same chemical drugs. In conclusion, these findings demonstrated the significance of lncRNA in metabolic regulation. These metabolism-related lncRNA regulators can improve our understanding of the underlying mechanism of lncRNAs and advance the research of immunotherapies in the clinical management of gastric cancer.
越来越多的证据表明，lncRNAs 在多种生物过程中是至关重要的调控因子，但 lncRNA 在代谢调控中的功能仍在很大程度上未被探索。在这项研究中，我们评估了 lncRNA 与代谢途径之间的关联，并确定了与代谢相关的 lncRNAs。基于这些与代谢相关的 lncRNA 调节剂，胃癌可主要分为 2 个簇。比较分析表明，这些亚型与基于其他组学数据鉴定的先前亚型高度一致。功能富集分析表明，它们富集在不同的生物学过程中。突变分析表明，ABCA13 在 C1 亚型中是一个保护因素，但在 C2 中是一个风险因素。对化疗和免疫治疗敏感性的分析表明，这些亚型对相同的化学药物表现出不同的敏感性。总之，这些发现表明 lncRNA 在代谢调控中的重要性。这些与代谢相关的 lncRNA 调节剂可以提高我们对 lncRNA 潜在机制的理解，并推进 lncRNA 在胃癌临床管理中的免疫治疗研究。
