骨转移癌的生物力学
Mechanobiology of Bone Metastatic Cancer.
机构信息
Department of Mechanical Engineering, University of Colorado, 427 UCB, Boulder, CO, 80309, USA.
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
出版信息
Curr Osteoporos Rep. 2021 Dec;19(6):580-591. doi: 10.1007/s11914-021-00704-9. Epub 2021 Nov 3.
Abstract
PURPOSE OF REVIEW
In this review, we provide an overview of what is currently known about the impacts of mechanical stimuli on metastatic tumor-induced bone disease (TIBD). Further, we focus on the role of the osteocyte, the skeleton's primary mechanosensory cell, which is central to the skeleton's mechanoresponse, sensing and integrating local mechanical stimuli, and then controlling the downstream remodeling balance as appropriate.
RECENT FINDINGS
Exercise and controlled mechanical loading have anabolic effects on bone tissue in models of bone metastasis. They also have anti-tumorigenic properties, in part due to offsetting the vicious cycle of osteolytic bone loss as well as regulating inflammatory signals. The impacts of metastatic cancer on the mechanosensory function of osteocytes remains unclear. Increased mechanical stimuli are a potential method for mitigating TIBD.
摘要
目的综述
在这篇综述中，我们概述了目前已知的机械刺激对转移性肿瘤诱导性骨病（TIBD）的影响。此外，我们专注于骨细胞的作用，骨细胞是骨骼的主要机械感受细胞，它是骨骼机械反应的核心，感知和整合局部机械刺激，然后适当地控制下游重塑平衡。
最近的发现
在骨转移模型中，运动和受控机械加载对骨组织具有合成代谢作用。它们还有抗肿瘤特性，部分原因是抵消溶骨性骨丢失的恶性循环以及调节炎症信号。转移性癌症对骨细胞机械感受功能的影响尚不清楚。增加机械刺激是减轻 TIBD 的一种潜在方法。
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