Division of Molecular Biochemistry, Medical Faculty, Rudolf Schönheimer Institute of Biochemistry, Leipzig University, Germany.
Stem Cell Institute, Ankara University, Turkey.
FEBS J. 2022 Dec;289(24):7610-7630. doi: 10.1111/febs.16258. Epub 2021 Nov 17.
Adhesion G protein-coupled receptors (aGPCRs) are a class of structurally and functionally highly intriguing cell surface receptors with essential functions in health and disease. Thus, they display a vastly unexploited pharmacological potential. Our current understanding of the physiological functions and signaling mechanisms of aGPCRs form the basis for elucidating further molecular aspects. Combining these with novel tools and methodologies from different fields tailored for studying these unusual receptors yields a powerful potential for pushing aGPCR research from singular approaches toward building up an in-depth knowledge that will facilitate its translation to applied science. In this review, we summarize the state-of-the-art knowledge on aGPCRs in respect to structure-function relations, physiology, and clinical aspects, as well as the latest advances in the field. We highlight the upcoming most pressing topics in aGPCR research and identify strategies to tackle them. Furthermore, we discuss approaches how to promote, stimulate, and translate research on aGPCRs 'from bench to bedside' in the future.
黏附 G 蛋白偶联受体（aGPCRs）是一类结构和功能上极具吸引力的细胞表面受体，在健康和疾病中具有重要功能。因此，它们显示出广泛未被开发的药理学潜力。我们目前对 aGPCR 的生理功能和信号转导机制的理解为进一步阐明分子方面奠定了基础。将这些与来自不同领域的用于研究这些不寻常受体的新工具和方法相结合，为推动 aGPCR 研究从单一方法向建立深入知识的方向发展提供了强大的潜力，这将有助于其向应用科学的转化。在这篇综述中，我们总结了关于 aGPCR 的结构-功能关系、生理学和临床方面的最新知识，以及该领域的最新进展。我们强调了 aGPCR 研究中即将面临的最紧迫的课题，并确定了解决这些课题的策略。此外，我们还讨论了未来如何促进、刺激和将 aGPCR 研究从“基础到临床”进行转化的方法。
