Pitikultham Piyawat, Wang Zhaoran, Wang Yiming, Shang Yingxu, Jiang Qiao, Ding Baoquan
CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, 11 BeiYiTiao ZhongGuanCun, Beijing, 100190, China.
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.
ChemMedChem. 2022 Jan 5;17(1):e202100635. doi: 10.1002/cmdc.202100635. Epub 2021 Nov 15.
DNA origami nanotechnology has provided predictable static nanoarchitectures and dynamic nanodevices with rationally designed geometries, precise spatial addressability, and marked biocompatibility. Multiple functional elements, such as peptides, aptamers, nanoparticles, fluorescence probes, and proteins, etc. can be easily integrated into DNA origami templates with nanoscale precision, leading to a variety of promising applications. Triggered by chemical/physical stimuli, dynamic DNA origami nanodevices can switch between defined conformations or translocate autonomously, providing powerful tools for intelligent biosensing and drug delivery. In this minireview, we summarize the recent progress of dynamic DNA origami nanodevices with desired reconfigurability and feasibility to perform multiple biological tasks. We introduce varieties of DNA nanodevices that can be controlled by different molecular triggers and external stimuli. Subsequently, we highlight the recent advances in employing DNA nanodevices as biosensors and drug delivery vehicles. At last, future possibilities and perspectives are also discussed.
DNA折纸纳米技术提供了具有合理设计的几何形状、精确的空间可寻址性和显著生物相容性的可预测静态纳米结构和动态纳米器件。多种功能元件，如肽、适体、纳米颗粒、荧光探针和蛋白质等，可以以纳米级精度轻松整合到DNA折纸模板中，从而带来各种有前景的应用。在化学/物理刺激的触发下，动态DNA折纸纳米器件可以在确定的构象之间切换或自主移位，为智能生物传感和药物递送提供了强大工具。在这篇综述中，我们总结了具有所需可重构性和可行性以执行多种生物学任务的动态DNA折纸纳米器件的最新进展。我们介绍了可以由不同分子触发因素和外部刺激控制的各种DNA纳米器件。随后，我们重点介绍了将DNA纳米器件用作生物传感器和药物递送载体的最新进展。最后，还讨论了未来的可能性和前景。
