Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven Celestijnenlaan 200F, 3001, Leuven, Belgium.
Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China.
Org Biomol Chem. 2021 Nov 18;19(44):9752-9757. doi: 10.1039/d1ob01805a.
A palladium-catalyzed intramolecular cyclization of Ugi-adducts a cascade dearomatization/aza-Michael addition process has been developed. Diverse plicamine analogues are constructed in a rapid, highly efficient and step-economical manner, through the combination of an Ugi-4CR and a palladium-catalyzed dearomatization. The synthetic utility of this approach is illustrated by further functional group transformations.
钯催化的 Ugi 加合物的分子内环化反应——级联去芳构化/氮杂-Michael 加成过程已经被开发出来。通过 Ugi-4CR 和钯催化的去芳构化反应的结合，以快速、高效和经济的方式构建了多种普卡灵类似物。该方法的合成实用性通过进一步的官能团转化得到了说明。
