Mikhelson A A, Pogorelova T N, Gunko V O, Nikashina A A, Palieva N V
Rostov State Medical University, Rostov-on-Don, Russia.
Biomed Khim. 2021 Sep;67(5):443-448. doi: 10.18097/PBMC20216705443.
The content of amino acids - sources of gasotransmitters and the activity of enzymes of their metabolism have been studied in the placenta and amniotic fluid in full-term and complicated by preterm birth (PB). Determination of amino acids was carried out using an automatic analyzer; specific spectrophotometric methods were used to assess the activity of enzymes. The development of PB is accompanied by changes in the amino acid level already in the second trimester of pregnancy. Correlation of differently directions was found between the level of amino acids and the activity of the corresponding enzymes. The imbalance of amino acids in the fetoplacental system in PB is accompanied by a change in the production of their low molecular weight derivatives gas transmitters (NO, CO, H2S), which play an important role in the regulation of numerous metabolic processes.
研究了足月和早产（PB）合并症患者胎盘和羊水中氨基酸的含量——气体递质的来源及其代谢酶的活性。使用自动分析仪测定氨基酸；采用特定的分光光度法评估酶的活性。早产的发生在妊娠中期就伴随着氨基酸水平的变化。发现氨基酸水平与相应酶的活性之间存在不同方向的相关性。早产时胎儿-胎盘系统中氨基酸的失衡伴随着其低分子量衍生物气体递质（NO、CO、H2S）产生的变化，这些气体递质在众多代谢过程的调节中起重要作用。
