Seah Jeffery Wee Kiong, Teo Ronald Hong Xiang, Leung Pak-Hing
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Dalton Trans. 2021 Nov 30;50(46):16909-16915. doi: 10.1039/d1dt03134a.
A number of palladacycles containing chiral chelating auxiliaries have been utilized as efficient catalysts for asymmetric hydrophosphination reactions. In all cases, the chiral auxiliaries remained coordinated to the palladium centres throughout the course of the reactions. Despite the presence of a large quantity of powerful tertiary phosphines, which are known to be strong metal ion sequesters, the expected catalyst poisoning was rarely observed in these palladacycle catalyzed processes. This review highlights the unique stereoelectronic features and the important organometallic chemistry of palladacycle catalysts which are essential to their synthetic operations.
一些含有手性螯合助剂的钯环已被用作不对称氢膦化反应的高效催化剂。在所有情况下，手性助剂在整个反应过程中都与钯中心保持配位。尽管存在大量已知是强金属离子螯合剂的强叔膦，但在这些钯环催化的过程中很少观察到预期的催化剂中毒现象。本综述强调了钯环催化剂独特的立体电子特征和重要的有机金属化学，这些对其合成操作至关重要。
