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茶与咖啡饮用与草酸钙肾结石风险之间的关联

The Associations Between Tea and Coffee Drinking and Risk of Calcium-Oxalate Renal Stones.

作者信息

Haghighatdoost Fahimeh, Sadeghian Reyhaneh, Abbasi Behnood

机构信息

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Shohadaye Hesarak Blvd, Daneshgah Square, Sattari Expressway, Tehran, 1477893855, Iran.

出版信息

Plant Foods Hum Nutr. 2021 Dec;76(4):516-522. doi: 10.1007/s11130-021-00933-4. Epub 2021 Nov 4.

Abstract

Findings regarding the association between tea and coffee consumption and oxalate-calcium stone are sparse and uncertain. The purpose of this study was to investigate the relations of tea and coffee with the risk of calcium oxalate stone formation. A total sample of 215 newly diagnosed patients with calcium oxalate stones and 215 controls matched for sex and age were recruited. Dietary intake of participants was assessed using a validated food frequency questionnaire over the preceding year and participants were asked to determine how many glasses of tea and cups of coffee they usually use. The associations between tea and coffee and kidney stone were examined using multivariable logistic regression. Compared with controls, cases had greater intake of tea (2.18±0.76 vs. 1.82±0.79 glasses/d) but lower intake of coffee (1.18±0.38 vs. 1.26±0.44 cups/week). After adjustment for potential confounders, compared with those who drank <2 glasses of tea/d, individuals with tea consumption of ≥4 glasses/d had greater risk for having calcium oxalate stone (OR= 2.73; 95 % CI: 1.50, 4.99). In the crude model, compared with coffee consumption for <1 cup/week, consumption of ≥1 cup/week was associated with a 38 % decrease in the risk of calcium oxalate stone. However, adjustment for potential confounders disappeared the significance (OR=0.81; 95 % CI: 0.48, 1.35). These results suggest that while high consumption of tea is associated with increased risk of calcium oxalate kidney stone, coffee drinking is not pertinent. However, due to low consumption of coffee in this population, our results should be interpreted cautiously.

摘要

关于茶和咖啡的摄入量与草酸钙结石之间关联的研究结果稀少且不确定。本研究的目的是调查茶和咖啡与草酸钙结石形成风险之间的关系。共招募了215名新诊断的草酸钙结石患者作为样本,并选取了215名年龄和性别相匹配的对照者。通过一份经过验证的食物频率问卷评估参与者前一年的饮食摄入量,并询问参与者他们通常饮用多少杯茶和咖啡。使用多变量逻辑回归分析茶和咖啡与肾结石之间的关联。与对照组相比,病例组的茶摄入量更高(2.18±0.76杯/天 vs. 1.82±0.79杯/天),但咖啡摄入量更低(1.18±0.38杯/周 vs. 1.26±0.44杯/周)。在对潜在混杂因素进行调整后,与每天饮用茶少于2杯的人相比,每天饮用茶≥4杯的个体患草酸钙结石的风险更高(OR = 2.73;95% CI:1.50,4.99)。在粗模型中,与每周饮用咖啡少于1杯相比,每周饮用咖啡≥1杯与草酸钙结石风险降低38%相关。然而,对潜在混杂因素进行调整后,这种相关性不再显著(OR = 0.81;95% CI:0.48,1.35)。这些结果表明,虽然大量饮茶与草酸钙肾结石风险增加有关,但喝咖啡与之无关。然而,由于该人群中咖啡摄入量较低,我们的结果应谨慎解读。

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